CILIA

Before and after

Peter Satir

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.

Original languageEnglish (US)
Article number1
JournalCilia
Volume6
Issue number1
DOIs
StatePublished - Mar 8 2017

Fingerprint

Cilia
Polycystic Kidney Diseases
Research
Genomics
Organelles
Proteomics

Keywords

  • Autophagy
  • Ciliary motility
  • Ciliogenesis
  • Ciliopathies
  • Intraflagellar transport (IFT)
  • Nucleoporin
  • Primary cilia
  • Transition zone

ASJC Scopus subject areas

  • Cell Biology

Cite this

CILIA : Before and after. / Satir, Peter.

In: Cilia, Vol. 6, No. 1, 1, 08.03.2017.

Research output: Contribution to journalReview article

Satir, Peter. / CILIA : Before and after. In: Cilia. 2017 ; Vol. 6, No. 1.
@article{6bc389d13cb44fa2a8c73d4e91f7cea4,
title = "CILIA: Before and after",
abstract = "This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.",
keywords = "Autophagy, Ciliary motility, Ciliogenesis, Ciliopathies, Intraflagellar transport (IFT), Nucleoporin, Primary cilia, Transition zone",
author = "Peter Satir",
year = "2017",
month = "3",
day = "8",
doi = "10.1186/s13630-017-0046-8",
language = "English (US)",
volume = "6",
journal = "Cilia",
issn = "2046-2530",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - CILIA

T2 - Before and after

AU - Satir, Peter

PY - 2017/3/8

Y1 - 2017/3/8

N2 - This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.

AB - This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.

KW - Autophagy

KW - Ciliary motility

KW - Ciliogenesis

KW - Ciliopathies

KW - Intraflagellar transport (IFT)

KW - Nucleoporin

KW - Primary cilia

KW - Transition zone

UR - http://www.scopus.com/inward/record.url?scp=85014755786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014755786&partnerID=8YFLogxK

U2 - 10.1186/s13630-017-0046-8

DO - 10.1186/s13630-017-0046-8

M3 - Review article

VL - 6

JO - Cilia

JF - Cilia

SN - 2046-2530

IS - 1

M1 - 1

ER -