CILIA: Before and after

Peter Satir

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.

Original languageEnglish (US)
Article number1
JournalCilia
Volume6
Issue number1
DOIs
StatePublished - Mar 8 2017

Keywords

  • Autophagy
  • Ciliary motility
  • Ciliogenesis
  • Ciliopathies
  • Intraflagellar transport (IFT)
  • Nucleoporin
  • Primary cilia
  • Transition zone

ASJC Scopus subject areas

  • Cell Biology

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