Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women

Geoffrey C. Kabat, Mimi Kim, Chandana Kakani, Hilary Tindle, Jean Wactawski-Wende, Judith K. Ockene, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In numerous studies, investigators have examined the association of active smoking with risk of invasive breast cancer, but to the authors' knowledge, no cohort study has assessed smoking in relation to the risk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer. The authors examined the latter association using data collected at baseline from 63,393 women in the Women's Health Initiative Clinical Trial. A total of 486 cases of ductal carcinoma in situ (DCIS) of the breast were identified during 8 years of follow-up between 1993 and 2005. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. For the primary analysis, invasive breast cancer was treated as a competing risk. After adjustment for covariates, associations with smoking status, smoking intensity, duration, pack-years, and age at quitting were all close to the null value and showed few meaningful trends. Sensitivity analyses performed to address different possibilities with respect to the natural history of breast cancer also did not provide consistent evidence of an association of smoking with DCIS. The results of this large cohort study provide little support for an association of cigarette smoking with risk of DCIS in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)591-599
Number of pages9
JournalAmerican Journal of Epidemiology
Volume172
Issue number5
DOIs
StatePublished - 2010

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Breast
Smoking
Breast Neoplasms
Cohort Studies
Women's Health
Proportional Hazards Models
Research Personnel
Clinical Trials
Confidence Intervals

Keywords

  • breast neoplasms
  • carcinoma, ductal, breast
  • carcinoma, intraductal, noninfiltrating
  • cohort studies
  • smoking

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. / Kabat, Geoffrey C.; Kim, Mimi; Kakani, Chandana; Tindle, Hilary; Wactawski-Wende, Jean; Ockene, Judith K.; Luo, Juhua; Wassertheil-Smoller, Sylvia; Rohan, Thomas E.

In: American Journal of Epidemiology, Vol. 172, No. 5, 2010, p. 591-599.

Research output: Contribution to journalArticle

Kabat, GC, Kim, M, Kakani, C, Tindle, H, Wactawski-Wende, J, Ockene, JK, Luo, J, Wassertheil-Smoller, S & Rohan, TE 2010, 'Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women', American Journal of Epidemiology, vol. 172, no. 5, pp. 591-599. https://doi.org/10.1093/aje/kwq159
Kabat, Geoffrey C. ; Kim, Mimi ; Kakani, Chandana ; Tindle, Hilary ; Wactawski-Wende, Jean ; Ockene, Judith K. ; Luo, Juhua ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E. / Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. In: American Journal of Epidemiology. 2010 ; Vol. 172, No. 5. pp. 591-599.
@article{77833d013b594102807affb65db87c2f,
title = "Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women",
abstract = "In numerous studies, investigators have examined the association of active smoking with risk of invasive breast cancer, but to the authors' knowledge, no cohort study has assessed smoking in relation to the risk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer. The authors examined the latter association using data collected at baseline from 63,393 women in the Women's Health Initiative Clinical Trial. A total of 486 cases of ductal carcinoma in situ (DCIS) of the breast were identified during 8 years of follow-up between 1993 and 2005. Cox proportional hazards models were used to estimate hazard ratios and 95{\%} confidence intervals. For the primary analysis, invasive breast cancer was treated as a competing risk. After adjustment for covariates, associations with smoking status, smoking intensity, duration, pack-years, and age at quitting were all close to the null value and showed few meaningful trends. Sensitivity analyses performed to address different possibilities with respect to the natural history of breast cancer also did not provide consistent evidence of an association of smoking with DCIS. The results of this large cohort study provide little support for an association of cigarette smoking with risk of DCIS in postmenopausal women.",
keywords = "breast neoplasms, carcinoma, ductal, breast, carcinoma, intraductal, noninfiltrating, cohort studies, smoking",
author = "Kabat, {Geoffrey C.} and Mimi Kim and Chandana Kakani and Hilary Tindle and Jean Wactawski-Wende and Ockene, {Judith K.} and Juhua Luo and Sylvia Wassertheil-Smoller and Rohan, {Thomas E.}",
year = "2010",
doi = "10.1093/aje/kwq159",
language = "English (US)",
volume = "172",
pages = "591--599",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Cigarette smoking in relation to risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women

AU - Kabat, Geoffrey C.

AU - Kim, Mimi

AU - Kakani, Chandana

AU - Tindle, Hilary

AU - Wactawski-Wende, Jean

AU - Ockene, Judith K.

AU - Luo, Juhua

AU - Wassertheil-Smoller, Sylvia

AU - Rohan, Thomas E.

PY - 2010

Y1 - 2010

N2 - In numerous studies, investigators have examined the association of active smoking with risk of invasive breast cancer, but to the authors' knowledge, no cohort study has assessed smoking in relation to the risk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer. The authors examined the latter association using data collected at baseline from 63,393 women in the Women's Health Initiative Clinical Trial. A total of 486 cases of ductal carcinoma in situ (DCIS) of the breast were identified during 8 years of follow-up between 1993 and 2005. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. For the primary analysis, invasive breast cancer was treated as a competing risk. After adjustment for covariates, associations with smoking status, smoking intensity, duration, pack-years, and age at quitting were all close to the null value and showed few meaningful trends. Sensitivity analyses performed to address different possibilities with respect to the natural history of breast cancer also did not provide consistent evidence of an association of smoking with DCIS. The results of this large cohort study provide little support for an association of cigarette smoking with risk of DCIS in postmenopausal women.

AB - In numerous studies, investigators have examined the association of active smoking with risk of invasive breast cancer, but to the authors' knowledge, no cohort study has assessed smoking in relation to the risk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer. The authors examined the latter association using data collected at baseline from 63,393 women in the Women's Health Initiative Clinical Trial. A total of 486 cases of ductal carcinoma in situ (DCIS) of the breast were identified during 8 years of follow-up between 1993 and 2005. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. For the primary analysis, invasive breast cancer was treated as a competing risk. After adjustment for covariates, associations with smoking status, smoking intensity, duration, pack-years, and age at quitting were all close to the null value and showed few meaningful trends. Sensitivity analyses performed to address different possibilities with respect to the natural history of breast cancer also did not provide consistent evidence of an association of smoking with DCIS. The results of this large cohort study provide little support for an association of cigarette smoking with risk of DCIS in postmenopausal women.

KW - breast neoplasms

KW - carcinoma, ductal, breast

KW - carcinoma, intraductal, noninfiltrating

KW - cohort studies

KW - smoking

UR - http://www.scopus.com/inward/record.url?scp=77956255700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956255700&partnerID=8YFLogxK

U2 - 10.1093/aje/kwq159

DO - 10.1093/aje/kwq159

M3 - Article

C2 - 20679068

AN - SCOPUS:77956255700

VL - 172

SP - 591

EP - 599

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 5

ER -