Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis

Further evidence for depolarization block

Jianping Chen, William Paredes, Eliot L. Gardner

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

As measured using in vivo brain microdialysis in conscious freely-moving rats, chronic treatment (20 mg/kg/day i.p. for 21 days) with the clinically atypical neurolepic clozapine selectively reduced basal dopamine (DA) release in the nucleus accumbens (Acb) but not in caudate-putamen (CPu). Apomorphine (100 μg/kg s.c.) enhanced presynaptic Acb DA release in clozapine-treated rats, but reduced Acb DA release in vehicle-treated rats. These findings provide further evidence that depolarization block of mesolimbic DA neurons projecting to Acb but not of nigrostriatal DA neurons projecting to CPu may underlie clozapine's unusual clinical efficacy and its lack of production of extrapyramidal motoric effects.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalNeuroscience Letters
Volume122
Issue number1
DOIs
StatePublished - Jan 14 1991

Fingerprint

Clozapine
Putamen
Microdialysis
Nucleus Accumbens
Dopamine
Dopaminergic Neurons
Brain
Apomorphine

Keywords

  • Caudate-putamen
  • Depolarization block
  • Dopamine
  • Microdialysis
  • Neuroleptic Clozapine
  • Nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{1dca8520af0a42138fdc29f7f397cc27,
title = "Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block",
abstract = "As measured using in vivo brain microdialysis in conscious freely-moving rats, chronic treatment (20 mg/kg/day i.p. for 21 days) with the clinically atypical neurolepic clozapine selectively reduced basal dopamine (DA) release in the nucleus accumbens (Acb) but not in caudate-putamen (CPu). Apomorphine (100 μg/kg s.c.) enhanced presynaptic Acb DA release in clozapine-treated rats, but reduced Acb DA release in vehicle-treated rats. These findings provide further evidence that depolarization block of mesolimbic DA neurons projecting to Acb but not of nigrostriatal DA neurons projecting to CPu may underlie clozapine's unusual clinical efficacy and its lack of production of extrapyramidal motoric effects.",
keywords = "Caudate-putamen, Depolarization block, Dopamine, Microdialysis, Neuroleptic Clozapine, Nucleus accumbens",
author = "Jianping Chen and William Paredes and Gardner, {Eliot L.}",
year = "1991",
month = "1",
day = "14",
doi = "10.1016/0304-3940(91)90209-C",
language = "English (US)",
volume = "122",
pages = "127--131",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis

T2 - Further evidence for depolarization block

AU - Chen, Jianping

AU - Paredes, William

AU - Gardner, Eliot L.

PY - 1991/1/14

Y1 - 1991/1/14

N2 - As measured using in vivo brain microdialysis in conscious freely-moving rats, chronic treatment (20 mg/kg/day i.p. for 21 days) with the clinically atypical neurolepic clozapine selectively reduced basal dopamine (DA) release in the nucleus accumbens (Acb) but not in caudate-putamen (CPu). Apomorphine (100 μg/kg s.c.) enhanced presynaptic Acb DA release in clozapine-treated rats, but reduced Acb DA release in vehicle-treated rats. These findings provide further evidence that depolarization block of mesolimbic DA neurons projecting to Acb but not of nigrostriatal DA neurons projecting to CPu may underlie clozapine's unusual clinical efficacy and its lack of production of extrapyramidal motoric effects.

AB - As measured using in vivo brain microdialysis in conscious freely-moving rats, chronic treatment (20 mg/kg/day i.p. for 21 days) with the clinically atypical neurolepic clozapine selectively reduced basal dopamine (DA) release in the nucleus accumbens (Acb) but not in caudate-putamen (CPu). Apomorphine (100 μg/kg s.c.) enhanced presynaptic Acb DA release in clozapine-treated rats, but reduced Acb DA release in vehicle-treated rats. These findings provide further evidence that depolarization block of mesolimbic DA neurons projecting to Acb but not of nigrostriatal DA neurons projecting to CPu may underlie clozapine's unusual clinical efficacy and its lack of production of extrapyramidal motoric effects.

KW - Caudate-putamen

KW - Depolarization block

KW - Dopamine

KW - Microdialysis

KW - Neuroleptic Clozapine

KW - Nucleus accumbens

UR - http://www.scopus.com/inward/record.url?scp=0025977365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025977365&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(91)90209-C

DO - 10.1016/0304-3940(91)90209-C

M3 - Article

VL - 122

SP - 127

EP - 131

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -