Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block

Jianping Chen, William Paredes, Eliot L. Gardner

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

As measured using in vivo brain microdialysis in conscious freely-moving rats, chronic treatment (20 mg/kg/day i.p. for 21 days) with the clinically atypical neurolepic clozapine selectively reduced basal dopamine (DA) release in the nucleus accumbens (Acb) but not in caudate-putamen (CPu). Apomorphine (100 μg/kg s.c.) enhanced presynaptic Acb DA release in clozapine-treated rats, but reduced Acb DA release in vehicle-treated rats. These findings provide further evidence that depolarization block of mesolimbic DA neurons projecting to Acb but not of nigrostriatal DA neurons projecting to CPu may underlie clozapine's unusual clinical efficacy and its lack of production of extrapyramidal motoric effects.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalNeuroscience Letters
Volume122
Issue number1
DOIs
StatePublished - Jan 14 1991

Keywords

  • Caudate-putamen
  • Depolarization block
  • Dopamine
  • Microdialysis
  • Neuroleptic Clozapine
  • Nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience(all)

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