TY - JOUR
T1 - Chronic Stress, Genetic Risk, and Obesity in US Hispanic/Latinos
T2 - Results From the Hispanic Community Health Study/Study of Latinos
AU - Isasi, Carmen R.
AU - Moon, Jee Young
AU - Gallo, Linda C.
AU - Qi, Qibin
AU - Wang, Tao
AU - Sotres-Alvarez, Daniela
AU - Llabre, Maria M.
AU - Khambaty, Tasneem
AU - Daviglus, Martha
AU - Estrella, Mayra L.
AU - Cai, Jianwen
AU - Kaplan, Robert
N1 - Funding Information:
Source of Funding and Conflicts of Interest: The authors do not report any conflict of interest. The Hispanic Community Health Study/Study of Latinos was supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), the University of Illinois at Chicago (HHSN268201300003I), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following institutes/centers/offices contributed to the Hispanic Community Health Study/Study of Latinos through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurologic Disorders and Stroke, and the Office of Dietary Supplements. Additional support was provided by grant R01MD013320 and the Life Course Methodology Core at Albert Einstein College of Medicine and the New York Regional Center for Diabetes Translation Research (P30 DK111022-8786 and P30 DK111022) through funds from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NHLBI or the National Institutes of Health.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2022/9
Y1 - 2022/9
N2 - Objective This study aimed to investigate whether the association of chronic stress with obesity is independent of genetic risk and test whether it varies by the underlying genetic risk. Methods The analysis included data from the Hispanic Community Health Study/Study of Latinos, a community-based study of Hispanic/Latinos living in four US communities (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). The sample consisted of 5336 women and 3231 men who attended the Hispanic Community Health Study/Study of Latinos second in-person examination, had measures of obesity, and chronic stress, and were genotyped. Chronic stress burden was assessed by an eight-item scale. An overall polygenic risk score was calculated based on the summary statistics from GIANT and UK BioBank meta-analysis of body mass index (BMI) genome-wide association studies. Mixed-effect models were used to account for genetic relatedness and sampling design, as well as to adjust for potential confounders. Results A higher number of chronic stressors were associated with both BMI (β [log odds] = 0.31 [95% confidence interval = 0.23-0.38]) and obesity (β [log odds] = 0.10 [95% confidence interval = 0.07-0.13]), after adjustment for covariates and genetic risk. No interactions were found between chronic stress and the genetic risk score for BMI or obesity. Conclusions We did not find evidence for an interaction between chronic stress and polygenic risk score, which was not consistent with other publications that showed greater BMI or obesity in the groups with high stressors and elevated genetic risk.
AB - Objective This study aimed to investigate whether the association of chronic stress with obesity is independent of genetic risk and test whether it varies by the underlying genetic risk. Methods The analysis included data from the Hispanic Community Health Study/Study of Latinos, a community-based study of Hispanic/Latinos living in four US communities (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA). The sample consisted of 5336 women and 3231 men who attended the Hispanic Community Health Study/Study of Latinos second in-person examination, had measures of obesity, and chronic stress, and were genotyped. Chronic stress burden was assessed by an eight-item scale. An overall polygenic risk score was calculated based on the summary statistics from GIANT and UK BioBank meta-analysis of body mass index (BMI) genome-wide association studies. Mixed-effect models were used to account for genetic relatedness and sampling design, as well as to adjust for potential confounders. Results A higher number of chronic stressors were associated with both BMI (β [log odds] = 0.31 [95% confidence interval = 0.23-0.38]) and obesity (β [log odds] = 0.10 [95% confidence interval = 0.07-0.13]), after adjustment for covariates and genetic risk. No interactions were found between chronic stress and the genetic risk score for BMI or obesity. Conclusions We did not find evidence for an interaction between chronic stress and polygenic risk score, which was not consistent with other publications that showed greater BMI or obesity in the groups with high stressors and elevated genetic risk.
KW - Abbreviations
KW - BMI = body mass index
KW - CI = confidence interval
KW - HCHS/SOL = Hispanic Community Health Study/Study of Latinos
KW - Hispanics/Latinos
KW - PRS = polygenic risk score
KW - SNPs = single nucleotide polymorphisms
KW - chronic stress
KW - genetic risk
KW - obesity
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U2 - 10.1097/PSY.0000000000001107
DO - 10.1097/PSY.0000000000001107
M3 - Article
C2 - 35797158
AN - SCOPUS:85137136600
SN - 0033-3174
VL - 84
SP - 822
EP - 827
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
IS - 7
ER -
