Chromosome 22q11 and schizophrenia

Soh Agatsuma, Noboru Hiroi

Research output: Contribution to journalArticle

Abstract

Several human chromosomal regions have been identified as candidate regions that play a role in schizophrenia. Deletion or duplication of chromosome 22q11 is associated with velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), a disorder associated with high rates of schizophrenia as well as physical abnormalities (i.e., cardiovascular, parathyroid, thymic and craniofacial abnormalities). Recent mouse studies have identified several candidate genes for VCFS/DGS within the mouse homologue chromosome 16. Deletion of Tbx1, Prodh and Comt within mouse chromosome 16 causes several physical and behavioral features of VCFS/DGS. As VCFS/DGS is likely to represent a genetic subtype of schizophrenia, pinpointing the genetic basis for this specific subtype will contribute to a better understanding of this neuropsychiatric disorder.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalJapanese Journal of Neuropsychopharmacology
Volume25
Issue number2
StatePublished - Apr 2005

Fingerprint

DiGeorge Syndrome
Schizophrenia
Chromosomes
Chromosomes, Human, Pair 16
Craniofacial Abnormalities
Chromosome Duplication
Cardiovascular Abnormalities

Keywords

  • Chromosome 22q11
  • Schizophrenia
  • VCFS/DGS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Agatsuma, S., & Hiroi, N. (2005). Chromosome 22q11 and schizophrenia. Japanese Journal of Neuropsychopharmacology, 25(2), 79-84.

Chromosome 22q11 and schizophrenia. / Agatsuma, Soh; Hiroi, Noboru.

In: Japanese Journal of Neuropsychopharmacology, Vol. 25, No. 2, 04.2005, p. 79-84.

Research output: Contribution to journalArticle

Agatsuma, S & Hiroi, N 2005, 'Chromosome 22q11 and schizophrenia', Japanese Journal of Neuropsychopharmacology, vol. 25, no. 2, pp. 79-84.
Agatsuma, Soh ; Hiroi, Noboru. / Chromosome 22q11 and schizophrenia. In: Japanese Journal of Neuropsychopharmacology. 2005 ; Vol. 25, No. 2. pp. 79-84.
@article{f27153108eac4332be96489e1cd6503e,
title = "Chromosome 22q11 and schizophrenia",
abstract = "Several human chromosomal regions have been identified as candidate regions that play a role in schizophrenia. Deletion or duplication of chromosome 22q11 is associated with velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), a disorder associated with high rates of schizophrenia as well as physical abnormalities (i.e., cardiovascular, parathyroid, thymic and craniofacial abnormalities). Recent mouse studies have identified several candidate genes for VCFS/DGS within the mouse homologue chromosome 16. Deletion of Tbx1, Prodh and Comt within mouse chromosome 16 causes several physical and behavioral features of VCFS/DGS. As VCFS/DGS is likely to represent a genetic subtype of schizophrenia, pinpointing the genetic basis for this specific subtype will contribute to a better understanding of this neuropsychiatric disorder.",
keywords = "Chromosome 22q11, Schizophrenia, VCFS/DGS",
author = "Soh Agatsuma and Noboru Hiroi",
year = "2005",
month = "4",
language = "English (US)",
volume = "25",
pages = "79--84",
journal = "Neuropsychopharmacology Reports",
issn = "1340-2544",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Chromosome 22q11 and schizophrenia

AU - Agatsuma, Soh

AU - Hiroi, Noboru

PY - 2005/4

Y1 - 2005/4

N2 - Several human chromosomal regions have been identified as candidate regions that play a role in schizophrenia. Deletion or duplication of chromosome 22q11 is associated with velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), a disorder associated with high rates of schizophrenia as well as physical abnormalities (i.e., cardiovascular, parathyroid, thymic and craniofacial abnormalities). Recent mouse studies have identified several candidate genes for VCFS/DGS within the mouse homologue chromosome 16. Deletion of Tbx1, Prodh and Comt within mouse chromosome 16 causes several physical and behavioral features of VCFS/DGS. As VCFS/DGS is likely to represent a genetic subtype of schizophrenia, pinpointing the genetic basis for this specific subtype will contribute to a better understanding of this neuropsychiatric disorder.

AB - Several human chromosomal regions have been identified as candidate regions that play a role in schizophrenia. Deletion or duplication of chromosome 22q11 is associated with velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS), a disorder associated with high rates of schizophrenia as well as physical abnormalities (i.e., cardiovascular, parathyroid, thymic and craniofacial abnormalities). Recent mouse studies have identified several candidate genes for VCFS/DGS within the mouse homologue chromosome 16. Deletion of Tbx1, Prodh and Comt within mouse chromosome 16 causes several physical and behavioral features of VCFS/DGS. As VCFS/DGS is likely to represent a genetic subtype of schizophrenia, pinpointing the genetic basis for this specific subtype will contribute to a better understanding of this neuropsychiatric disorder.

KW - Chromosome 22q11

KW - Schizophrenia

KW - VCFS/DGS

UR - http://www.scopus.com/inward/record.url?scp=19744366937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19744366937&partnerID=8YFLogxK

M3 - Article

C2 - 16220657

AN - SCOPUS:19744366937

VL - 25

SP - 79

EP - 84

JO - Neuropsychopharmacology Reports

JF - Neuropsychopharmacology Reports

SN - 1340-2544

IS - 2

ER -