Chromosomal proteins of rat brain: increased synthesis and affinity for DNA following a pulse of the carcinogen ethylnitrosourea in vivo

Leonard H. Augenlicht, H. Biessmann, M. F. Rajewsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A single pulse of ethylnitrosourea (EtNU), administered to 10 day old BD IX rats, specifically results in a high incidence of neuroectodermal tumors in the central and peripheral nervous system. At five days after an EtNU pulse, analyses of protein DNA interactions were performed using chromatin dissociation and re association experiments, following incorporation of radioactive leucine into brain chromosomal proteins (CP) during short term suspension culture. In comparison with 15 day old control animals, the brain cells of EtNU treated rats exhibited an increased rate of CP synthesis, and an increased affinity of the newly synthesized CP for brain DNA of both control and EtNU treated animals.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalJournal of Cellular Physiology
Volume86
Issue number2 II
StatePublished - 1975
Externally publishedYes

Fingerprint

Ethylnitrosourea
Carcinogens
Rats
Brain
DNA
Animals
Proteins
Neuroectodermal Tumors
Peripheral Nervous System
Neurology
Leucine
Chromatin
Tumors
Suspensions
Central Nervous System
Association reactions
Incidence
Experiments

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Physiology

Cite this

Chromosomal proteins of rat brain : increased synthesis and affinity for DNA following a pulse of the carcinogen ethylnitrosourea in vivo. / Augenlicht, Leonard H.; Biessmann, H.; Rajewsky, M. F.

In: Journal of Cellular Physiology, Vol. 86, No. 2 II, 1975, p. 431-438.

Research output: Contribution to journalArticle

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