Chromosomal location of murine and human IL-1 receptor genes

Neal G. Copeland; Colleen M. Silan; David M. Kingsley; Nancy A. Jenkins; Linda A. Cannizzaro; Carlo M. Croce; Kay Huebner; John E. Sims

doi:10.1016/0888-7543(91)90219-5

Chromosomal location of murine and human IL-1 receptor genes

Neal G. Copeland, Colleen M. Silan, David M. Kingsley, Nancy A. Jenkins, Linda A. Cannizzaro, Carlo M. Croce, Kay Huebner, John E. Sims

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2.

Original language	English (US)
Pages (from-to)	44-50
Number of pages	7
Journal	Genomics
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(91)90219-5
State	Published - Jan 1991
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Chromosomal location of murine and human IL-1 receptor genes",

abstract = "The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2.",

author = "Copeland, {Neal G.} and Silan, {Colleen M.} and Kingsley, {David M.} and Jenkins, {Nancy A.} and Cannizzaro, {Linda A.} and Croce, {Carlo M.} and Kay Huebner and Sims, {John E.}",

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AU - Copeland, Neal G.

AU - Silan, Colleen M.

AU - Kingsley, David M.

AU - Jenkins, Nancy A.

AU - Cannizzaro, Linda A.

AU - Croce, Carlo M.

AU - Huebner, Kay

AU - Sims, John E.

PY - 1991/1

Y1 - 1991/1

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AB - The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2.

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Chromosomal location of murine and human IL-1 receptor genes

Abstract

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