Chromosomal location of murine and human IL-1 receptor genes

Neal G. Copeland, Colleen M. Silan, David M. Kingsley, Nancy A. Jenkins, Linda A. Cannizzaro, Carlo M. Croce, Kay Huebner, John E. Sims

Research output: Contribution to journalArticle

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Abstract

The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalGenomics
Volume9
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

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Interleukin-1 Receptors
Chromosomes, Human, Pair 2
Interleukin-1
Genes
Interleukin-1 Type I Receptors
Hybrid Cells
Chromosomes, Human, Pair 1
Human Chromosomes
Human Genome
Restriction Fragment Length Polymorphisms
In Situ Hybridization
Rodentia

ASJC Scopus subject areas

  • Genetics

Cite this

Copeland, N. G., Silan, C. M., Kingsley, D. M., Jenkins, N. A., Cannizzaro, L. A., Croce, C. M., ... Sims, J. E. (1991). Chromosomal location of murine and human IL-1 receptor genes. Genomics, 9(1), 44-50. https://doi.org/10.1016/0888-7543(91)90219-5

Chromosomal location of murine and human IL-1 receptor genes. / Copeland, Neal G.; Silan, Colleen M.; Kingsley, David M.; Jenkins, Nancy A.; Cannizzaro, Linda A.; Croce, Carlo M.; Huebner, Kay; Sims, John E.

In: Genomics, Vol. 9, No. 1, 1991, p. 44-50.

Research output: Contribution to journalArticle

Copeland, NG, Silan, CM, Kingsley, DM, Jenkins, NA, Cannizzaro, LA, Croce, CM, Huebner, K & Sims, JE 1991, 'Chromosomal location of murine and human IL-1 receptor genes', Genomics, vol. 9, no. 1, pp. 44-50. https://doi.org/10.1016/0888-7543(91)90219-5
Copeland NG, Silan CM, Kingsley DM, Jenkins NA, Cannizzaro LA, Croce CM et al. Chromosomal location of murine and human IL-1 receptor genes. Genomics. 1991;9(1):44-50. https://doi.org/10.1016/0888-7543(91)90219-5
Copeland, Neal G. ; Silan, Colleen M. ; Kingsley, David M. ; Jenkins, Nancy A. ; Cannizzaro, Linda A. ; Croce, Carlo M. ; Huebner, Kay ; Sims, John E. / Chromosomal location of murine and human IL-1 receptor genes. In: Genomics. 1991 ; Vol. 9, No. 1. pp. 44-50.
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