Chromosomal aneuploidy in the aging brain

Francesca Faggioli; Jan Vijg; Cristina Montagna

doi:10.1016/j.mad.2011.04.008

Chromosomal aneuploidy in the aging brain

Francesca Faggioli, Jan Vijg, Cristina Montagna

Genetics

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Mechanisms that govern genome integrity and stability are major guarantors of viability and longevity. As people age, memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases. The biological mechanisms underlying this age-related neuronal decline are not well understood. Genome instability has been implicated in neurodegenerative processes in aging and disease. Aneuploidy, a chromosome content that deviates from a diploid genome, is a recognized form of genomic instability. Here, we will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies.

Original language	English (US)
Pages (from-to)	429-436
Number of pages	8
Journal	Mechanisms of Ageing and Development
Volume	132
Issue number	8-9
DOIs	https://doi.org/10.1016/j.mad.2011.04.008
State	Published - Aug 2011

Keywords

Aging
Aneuploidy
Brain
Genome integrity

ASJC Scopus subject areas

Aging
Developmental Biology

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10.1016/j.mad.2011.04.008

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abstract = "Mechanisms that govern genome integrity and stability are major guarantors of viability and longevity. As people age, memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases. The biological mechanisms underlying this age-related neuronal decline are not well understood. Genome instability has been implicated in neurodegenerative processes in aging and disease. Aneuploidy, a chromosome content that deviates from a diploid genome, is a recognized form of genomic instability. Here, we will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies.",

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AU - Vijg, Jan

AU - Montagna, Cristina

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AB - Mechanisms that govern genome integrity and stability are major guarantors of viability and longevity. As people age, memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases. The biological mechanisms underlying this age-related neuronal decline are not well understood. Genome instability has been implicated in neurodegenerative processes in aging and disease. Aneuploidy, a chromosome content that deviates from a diploid genome, is a recognized form of genomic instability. Here, we will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies.

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Chromosomal aneuploidy in the aging brain

Abstract

Keywords

ASJC Scopus subject areas

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