Chemotherapy in non-small cell lung cancer

Results of recent trials

Richard J. Gralla, Mark G. Kris

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Several recent studies in non-small cell lung cancer (NSCLC) have helped to clarify the role of chemotherapy in patients with this disease. The objective of this communication is to briefly review some of the more important topics in the treatment of NSCLC. The more effective available combination regimens are based on single agents that have shown efficacy in phase II trials. Of additional importance is the use of the single agents in the same dosage and schedules in which the activity was originally reported. The question of the influence of chemotherapy on survival is discussed in terms of (1) the significant prognostic factors, including performance status, serum LDH level, and the presence of extrathoracic disease, including the influence of bone metastases, and (2) two recent trials comparing chemotherapy with supportive care in patients with unresectable NSCLC. Several recent trials have approached the question of preoperative or neoadjuvant chemotherapy in patients with advanced intrathoracic tumor. These trials have provided provocative results that indicate that combined modality approaches will continue to be interesting topics of clinical research in the near future.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalSeminars in Oncology
Volume15
Issue number3 SUPPL. 4
StatePublished - 1988
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Drug Therapy
Patient Care
Appointments and Schedules
Neoplasm Metastasis
Bone and Bones
Survival
Serum
Research
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Oncology

Cite this

Chemotherapy in non-small cell lung cancer : Results of recent trials. / Gralla, Richard J.; Kris, Mark G.

In: Seminars in Oncology, Vol. 15, No. 3 SUPPL. 4, 1988, p. 2-5.

Research output: Contribution to journalArticle

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