Chemokines in ischemia and reperfusion

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Chemokine signaling plays an important role in the post-ischemic inflammatory response. Overlapping pathways involving reactive oxygen intermediates, Toll-like receptor (TLR) activation, the complement cascade and the nuclear factor (NF)-κB system induce both CXC and CC chemokines in ischemic tissues. Reperfusion accentuates chemokine expression promoting an intense inflammatory reaction. ELR-containing CXC chemokines regulate neutrophil infiltration in the ischemic area, whereas CXCR3 ligands may mediate recruitment of ThI cells. CC chemokines, on the other hand, induce mononuclear cell infiltration and macrophage activation. Evidence suggests that chemokine signaling mediates actions beyond leukocyte chemotaxis and activation, regulating angiogenesis and fibrous tissue deposition. Effective repair of ischemic tissue is dependent on a well-orchestrated cellular response and on timely induction and suppression of chemokines in a locally restricted manner. This manuscript reviews the evidence suggesting a role for chemokine-mediated effects in ischemia/reperfusion and discusses the potential significance of these interactions in injury and repair of ischemic tissues.

Original languageEnglish (US)
Pages (from-to)738-747
Number of pages10
JournalThrombosis and Haemostasis
Volume97
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Chemokines
Reperfusion
Ischemia
CXC Chemokines
CC Chemokines
Leukocyte Chemotaxis
Macrophage Activation
Neutrophil Infiltration
Complement Activation
Toll-Like Receptors
Oxygen
Ligands
Wounds and Injuries

Keywords

  • Chemokine
  • Inflammation
  • Ischemia
  • Leukocyte
  • Reperfusion

ASJC Scopus subject areas

  • Hematology

Cite this

Chemokines in ischemia and reperfusion. / Frangogiannis, Nikolaos G.

In: Thrombosis and Haemostasis, Vol. 97, No. 5, 05.2007, p. 738-747.

Research output: Contribution to journalArticle

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