Chemical probing of glycans in cells and organisms

Sara H. Rouhanifard, Lars Ulrik Nordstrøm, Tianqing Zheng, Peng Wu

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Among the four major building blocks of life, glycans play essential roles in numerous physiological and pathological processes. Due to their non-templated biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively slow compared with the pace of protein and nucleic acid research. Over the past 30 years, chemical tools have emerged as powerful allies to genetics and molecular biology in the study of glycans in their native environment. This tutorial review will provide an overview of the recent technological developments in the field, as well as the progress in the application of these techniques to probe glycans in cells and organisms.

Original languageEnglish (US)
Pages (from-to)4284-4296
Number of pages13
JournalChemical Society Reviews
Volume42
Issue number10
DOIs
StatePublished - Apr 29 2013

ASJC Scopus subject areas

  • Chemistry(all)

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