TY - JOUR
T1 - Chemical probing of glycans in cells and organisms
AU - Rouhanifard, Sara H.
AU - Ulrik Nordstrøm, Lars
AU - Zheng, Tianqing
AU - Wu, Peng
PY - 2013/4/29
Y1 - 2013/4/29
N2 - Among the four major building blocks of life, glycans play essential roles in numerous physiological and pathological processes. Due to their non-templated biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively slow compared with the pace of protein and nucleic acid research. Over the past 30 years, chemical tools have emerged as powerful allies to genetics and molecular biology in the study of glycans in their native environment. This tutorial review will provide an overview of the recent technological developments in the field, as well as the progress in the application of these techniques to probe glycans in cells and organisms.
AB - Among the four major building blocks of life, glycans play essential roles in numerous physiological and pathological processes. Due to their non-templated biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively slow compared with the pace of protein and nucleic acid research. Over the past 30 years, chemical tools have emerged as powerful allies to genetics and molecular biology in the study of glycans in their native environment. This tutorial review will provide an overview of the recent technological developments in the field, as well as the progress in the application of these techniques to probe glycans in cells and organisms.
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U2 - 10.1039/c2cs35416k
DO - 10.1039/c2cs35416k
M3 - Article
C2 - 23257905
AN - SCOPUS:84876891395
SN - 0306-0012
VL - 42
SP - 4284
EP - 4296
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 10
ER -