Characterization of the North American beaver (Castor canadensis) papillomavirus genome

Artem S. Rogovskyy, Zigui Chen, Robert D. Burk, Troy Bankhead

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cutaneous exophytic lesions. In the current study, we determined the sequence of the complete 7435 basepair genome of CcanPV1. The genome contains an Upstream Regulatory Region located between the end of L1 and the start of E6, and seven canonical papillomavirus open reading frames encoding five early (E6, E7, E1, E2, and E4) and two late (L2 and L1) proteins. No E5 open reading frame was detected. Phylogenetic analysis of the CcanPV1 genome places the virus between the genera Kappapapillomavirus and Mupapillomavirus. Analyses of the papillomavirus genomes detected in different species of the order Rodentia indicate these viruses do not form a monophyletic clade.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalVeterinary Microbiology
Volume168
Issue number1
DOIs
StatePublished - Jan 10 2014

Fingerprint

Castor canadensis
Papillomaviridae
Rodentia
Genome
genome
Kappapapillomavirus
Mupapillomavirus
Viruses
viruses
Open Reading Frames
open reading frames
Skin
Nucleic Acid Regulatory Sequences
skin lesions
skin (animal)
mucosa
Mucous Membrane
epithelium
Epithelium
phylogeny

Keywords

  • Castor canadensis papillomavirus
  • CcanPV1
  • North American beaver
  • Papillomavirus

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Characterization of the North American beaver (Castor canadensis) papillomavirus genome. / Rogovskyy, Artem S.; Chen, Zigui; Burk, Robert D.; Bankhead, Troy.

In: Veterinary Microbiology, Vol. 168, No. 1, 10.01.2014, p. 214-220.

Research output: Contribution to journalArticle

Rogovskyy, Artem S. ; Chen, Zigui ; Burk, Robert D. ; Bankhead, Troy. / Characterization of the North American beaver (Castor canadensis) papillomavirus genome. In: Veterinary Microbiology. 2014 ; Vol. 168, No. 1. pp. 214-220.
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