Characterization of genital human papillomavirus infection in women who have or who are at risk of having HIV infection

Denise J. Jamieson, Ann Duerr, Robert D. Burk, Robert S. Klein, Pangaja Paramsothy, Paula Schuman, Susan Cu-Uvin, Keerti Shah

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to describe the prevalence of human papillomavirus infection and the likelihood of human papillomavirus expression and Papanicolaou test abnormalities among women who have and who are at risk of having human immunodeficiency virus infection. STUDY DESIGN: Cross-sectional analysis of 767 women who had human immunodeficiency virus infection and 390 women who were at risk of having human immunodeficiency virus infection in 4 cities in the United States. RESULTS: Women who were infected with human immunodeficiency virus were more likely than women who were not infected to have human papillomavirus infection (prevalence ratio, 2.3; 95% Cl, 2.0-2.8) but had similar human papillomavirus types. Among women who tested positive for human papillomavirus by polymerase chain reaction, human immunodeficiency virus infection was associated with a high level of human papillomavirus expression (prevalence ratio, 1.3-1.6) and multiple human papillomavirus infections (prevalence ratio, 1.9). However, among women with a high level of human papillomavirus expression or infection with multiple types, there was no association between human immunodeficiency virus serostatus and risk of cervical dysplasia. CONCLUSION: Through its association with a high level of expression and multiple human papillomavirus infections, human immunodeficiency virus infection may increase the risk of cervical dysplasia in women who are infected with human papillomavirus.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume186
Issue number1
DOIs
StatePublished - 2002

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Papillomavirus Infections
HIV Infections
Virus Diseases
HIV
Uterine Cervical Dysplasia
Papanicolaou Test
Cross-Sectional Studies
Polymerase Chain Reaction

Keywords

  • HIV
  • Human papillomavirus

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Characterization of genital human papillomavirus infection in women who have or who are at risk of having HIV infection. / Jamieson, Denise J.; Duerr, Ann; Burk, Robert D.; Klein, Robert S.; Paramsothy, Pangaja; Schuman, Paula; Cu-Uvin, Susan; Shah, Keerti.

In: American Journal of Obstetrics and Gynecology, Vol. 186, No. 1, 2002, p. 21-27.

Research output: Contribution to journalArticle

Jamieson, Denise J. ; Duerr, Ann ; Burk, Robert D. ; Klein, Robert S. ; Paramsothy, Pangaja ; Schuman, Paula ; Cu-Uvin, Susan ; Shah, Keerti. / Characterization of genital human papillomavirus infection in women who have or who are at risk of having HIV infection. In: American Journal of Obstetrics and Gynecology. 2002 ; Vol. 186, No. 1. pp. 21-27.
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