Chapter 7: Achievements and limitations of cervical cytology screening

Henry C. Kitchener, Philip E. Castle, J. Thomas Cox

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

This chapter reviews the contribution of cervical cytology, what makes it successful, the management of screen positives and how technological advances may affect its use in the future. Cervical screening has saved hundreds of thousands of lives but has not been available to women in the poorest countries. In countries where wide coverage has been achieved and quality assurance is in place, incidence and death rates have fallen by over 50% even though cervical cytology is logistically complex. The management of high-grade cervical intraepithelial neoplasia (CIN) is very effective, but low-grade cytological abnormalities require care to avoid over-treatment. The increasing rate of human papillomavirus (HPV) testing and the prospect of prophylactic vaccination will change the way cervical cytology is used, possibly giving way to HPV testing as the primary test in secondary prevention.

Original languageEnglish (US)
JournalVaccine
Volume24
Issue numberSUPPL. 3
DOIs
StatePublished - Aug 21 2006
Externally publishedYes

Fingerprint

cell biology
Cell Biology
Papillomaviridae
screening
Cervical Intraepithelial Neoplasia
testing
Secondary Prevention
quality control
Vaccination
vaccination
incidence
neoplasms
Mortality
Incidence
Therapeutics

Keywords

  • Cervical
  • Cytology
  • Screening

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Chapter 7 : Achievements and limitations of cervical cytology screening. / Kitchener, Henry C.; Castle, Philip E.; Cox, J. Thomas.

In: Vaccine, Vol. 24, No. SUPPL. 3, 21.08.2006.

Research output: Contribution to journalArticle

Kitchener, Henry C. ; Castle, Philip E. ; Cox, J. Thomas. / Chapter 7 : Achievements and limitations of cervical cytology screening. In: Vaccine. 2006 ; Vol. 24, No. SUPPL. 3.
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