Chaperone-mediated autophagy: Roles in disease and aging

Ana Maria Cuervo, Esther Wong

Research output: Contribution to journalReview article

382 Scopus citations

Abstract

This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate proteins are selectively targeted to lysosomes and translocated into the lysosomal lumen through the coordinated action of chaperones located at both sides of the membrane and a dedicated protein translocation complex. The selectivity of CMA permits timed degradation of specific proteins with regulatory purposes supporting a modulatory role for CMA in enzymatic metabolic processes and subsets of the cellular transcriptional program. In addition, CMA contributes to cellular quality control through the removal of damaged or malfunctioning proteins. Here, we describe recent advances in the understanding of the molecular dynamics, regulation and physiology of CMA, and discuss the evidence in support of the contribution of CMA dysfunction to severe human disorders such as neurodegeneration and cancer.

Original languageEnglish (US)
Pages (from-to)92-104
Number of pages13
JournalCell Research
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2014

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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