Changes in the sialic acid concentration in the major cervical glycoprotein from the bonnet monkey (Macaca radiata) during a hormonally induced cycle

Victor Bernard Hatcher, G. O H Schwarzmann, R. W. Jeanloz, J. W. McArthur

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The major macromolecular component of monkey cervical mucus has been purified from crude monkey cervical mucus at various times during a hormonally induced estrous cycle. The major component, a high-molecular weight glycoprotein, was secreted in large amounts in midcycle mucus. The glycoprotein exhibited human blood group B activity and contained the same concentration of L-fucose, D-galactose, N-acetyl-D-galactosamine, and N-acetyl-D-glucosamine during the cycle. There were no changes in the amino acid composition or in the number of carbohydrate side chains. There was a significant increase in the amount of sialic acid in the glycoprotein purified from midcycle mucus. Changes in the specific viscosity and the far ultraviolet circular dichroic spectra were also observed. The possible control of sperm penetration by the glycoprotein is discussed.

Original languageEnglish (US)
Pages (from-to)682-688
Number of pages7
JournalFertility and Sterility
Volume28
Issue number6
StatePublished - 1977
Externally publishedYes

Fingerprint

Macaca radiata
N-Acetylneuraminic Acid
Glycoproteins
Cervix Mucus
Mucus
Haplorhini
Sperm-Ovum Interactions
Acetylgalactosamine
Fucose
Estrous Cycle
Acetylglucosamine
Blood Group Antigens
Galactose
Viscosity
Molecular Weight
Carbohydrates
Amino Acids

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Changes in the sialic acid concentration in the major cervical glycoprotein from the bonnet monkey (Macaca radiata) during a hormonally induced cycle. / Hatcher, Victor Bernard; Schwarzmann, G. O H; Jeanloz, R. W.; McArthur, J. W.

In: Fertility and Sterility, Vol. 28, No. 6, 1977, p. 682-688.

Research output: Contribution to journalArticle

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