Changes in 31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors

J. A. Koutcher, A. A. Alfieri, D. C. Barnett, David Cowburn, A. B. Kornblith, J. H. Kim

Research output: Contribution to journalArticle

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Abstract

In vivo 31P nuclear magnetic resonance (31P NMR) spectroscopy has been used to compare metabolic profile with tumor radiosensitivity. A radioresistant mammary carcinoma (MCa) and a radiosensitive methylcholanthrene-induced fibrosarcoma (Meth-A) were studied by 31P NMR spectroscopy in the tumor volume range of approximately 100-1200 mm3. The MCa showed a constant pH in this volume range; the ratio of phosphocreatine to inorganic phosphate (PCr/P(i)) for 160-300 mm3 tumors was 0.33 ± 0.11 (mean ± standard deviation) and did not change (0.29 ± .09) for tumors in the volume range of 600-1200 mm3. In comparison, the Meth-A showed a decrease in tumor pH as volume increased from 160-300 mm3 (pH 7.16 ± .04) to 600-1200 mm3 (pH 6.94 ± .07). Tumor PCr/P(i) decreased from 0.70 ± .16 (160-300 mm3) to 0.33 ± .16 (600-1200 mm3). The radiation doses for control of MCa-induced tumors in 50% of the treated tumors ranged from 65 (150-250 mm3) to 71 Gy (1000-1300 mm3) and for the Meth-A-induced tumors ranged from 35 (150-250 mm3) to 38 Gy (1000-1300 mm3). These results sugest that 31P NMR spectra may be a qualitative predictor of tumor hypoxia, although further studies of human and rodent tumors are necessary to support this hypothesis.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalRadiation Research
Volume121
Issue number3
StatePublished - 1990

Fingerprint

nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
tumors
nuclear magnetic resonance
neoplasms
Growth
Methylcholanthrene
Fibrosarcoma
Neoplasms
fibrosarcoma
Breast Neoplasms
breast neoplasms
Tumor Burden
cancer
magnetic resonance spectroscopy
Phosphocreatine
Metabolome
Radiation Tolerance
phosphocreatine
rodents

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Koutcher, J. A., Alfieri, A. A., Barnett, D. C., Cowburn, D., Kornblith, A. B., & Kim, J. H. (1990). Changes in 31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors. Radiation Research, 121(3), 312-319.

Changes in 31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors. / Koutcher, J. A.; Alfieri, A. A.; Barnett, D. C.; Cowburn, David; Kornblith, A. B.; Kim, J. H.

In: Radiation Research, Vol. 121, No. 3, 1990, p. 312-319.

Research output: Contribution to journalArticle

Koutcher, JA, Alfieri, AA, Barnett, DC, Cowburn, D, Kornblith, AB & Kim, JH 1990, 'Changes in 31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors', Radiation Research, vol. 121, no. 3, pp. 312-319.
Koutcher, J. A. ; Alfieri, A. A. ; Barnett, D. C. ; Cowburn, David ; Kornblith, A. B. ; Kim, J. H. / Changes in 31P nuclear magnetic resonance with tumor growth in radioresistant and radiosensitive tumors. In: Radiation Research. 1990 ; Vol. 121, No. 3. pp. 312-319.
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