Change in circulating adiponectin in advanced old age

Determinants and impact on physical function and mortality. the cardiovascular health study all stars study

Jorge Kizer, Alice M. Arnold, Elsa S. Strotmeyer, Diane G. Ives, Mary Cushman, Jingzhong Ding, Stephen B. Kritchevsky, Paulo H M Chaves, Calvin H. Hirsch, Anne B. Newman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background. Cross-sectional studies show that adiponectin is higher in older than in younger adults but long-term change in adiponectin, its determinants, and its relationship to functional decline or survival in the elderly population have not been evaluated. Methods. We investigated predictors of longitudinal change in adiponectin, and the association of this adipokine or its antecedent change with physical deterioration and all-cause mortality in 988 participants in a population-based study who completed examinations in 1996-1997 and 2005-2006, had serial adiponectin measurements and underwent follow-up through June 2009. Results. Adiponectin level rose significantly during follow-up, but the increase was smaller in blacks, was associated with declining weight or fasting glucose and, in men, lower albumin, and was affected by medications. Adiponectin was independently associated with greater physical decline, but the relationship for adiponectin change was driven by concomitant weight decrease. Both adiponectin and its change independently predicted mortality, even after adjustment for weight change. The association for adiponectin and mortality was observed in whites but not in blacks and only for levels in the upper range (hazard ratio = 1.85, 95% confidence interval = 1.36-2.52 per SD ≥ 20 mg/L), whereas that for adiponectin change was linear throughout in both racial groups (hazard ratio = 1.30, 95% confidence interval = 1.10-1.52 per SD). Conclusions. Adiponectin levels increase over time in long-lived adults and are associated with greater physical disability and mortality. Such increases may occur in response to age-related homeostatic dysregulation. Additional investigation is required to define the underlying mechanisms and whether this represents a marker or causal factor for mortality in this age group.

Original languageEnglish (US)
Pages (from-to)1208-1214
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume65 A
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Adiponectin
Mortality
Health
Weights and Measures
Confidence Intervals
Adipokines
Population
Young Adult
Albumins
Fasting
Age Groups
Cross-Sectional Studies
Glucose

Keywords

  • Adiponectin
  • Aging
  • Mortality
  • Physical Function

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Change in circulating adiponectin in advanced old age : Determinants and impact on physical function and mortality. the cardiovascular health study all stars study. / Kizer, Jorge; Arnold, Alice M.; Strotmeyer, Elsa S.; Ives, Diane G.; Cushman, Mary; Ding, Jingzhong; Kritchevsky, Stephen B.; Chaves, Paulo H M; Hirsch, Calvin H.; Newman, Anne B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 65 A, No. 11, 11.2010, p. 1208-1214.

Research output: Contribution to journalArticle

Kizer, Jorge ; Arnold, Alice M. ; Strotmeyer, Elsa S. ; Ives, Diane G. ; Cushman, Mary ; Ding, Jingzhong ; Kritchevsky, Stephen B. ; Chaves, Paulo H M ; Hirsch, Calvin H. ; Newman, Anne B. / Change in circulating adiponectin in advanced old age : Determinants and impact on physical function and mortality. the cardiovascular health study all stars study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2010 ; Vol. 65 A, No. 11. pp. 1208-1214.
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abstract = "Background. Cross-sectional studies show that adiponectin is higher in older than in younger adults but long-term change in adiponectin, its determinants, and its relationship to functional decline or survival in the elderly population have not been evaluated. Methods. We investigated predictors of longitudinal change in adiponectin, and the association of this adipokine or its antecedent change with physical deterioration and all-cause mortality in 988 participants in a population-based study who completed examinations in 1996-1997 and 2005-2006, had serial adiponectin measurements and underwent follow-up through June 2009. Results. Adiponectin level rose significantly during follow-up, but the increase was smaller in blacks, was associated with declining weight or fasting glucose and, in men, lower albumin, and was affected by medications. Adiponectin was independently associated with greater physical decline, but the relationship for adiponectin change was driven by concomitant weight decrease. Both adiponectin and its change independently predicted mortality, even after adjustment for weight change. The association for adiponectin and mortality was observed in whites but not in blacks and only for levels in the upper range (hazard ratio = 1.85, 95{\%} confidence interval = 1.36-2.52 per SD ≥ 20 mg/L), whereas that for adiponectin change was linear throughout in both racial groups (hazard ratio = 1.30, 95{\%} confidence interval = 1.10-1.52 per SD). Conclusions. Adiponectin levels increase over time in long-lived adults and are associated with greater physical disability and mortality. Such increases may occur in response to age-related homeostatic dysregulation. Additional investigation is required to define the underlying mechanisms and whether this represents a marker or causal factor for mortality in this age group.",
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T2 - Determinants and impact on physical function and mortality. the cardiovascular health study all stars study

AU - Kizer, Jorge

AU - Arnold, Alice M.

AU - Strotmeyer, Elsa S.

AU - Ives, Diane G.

AU - Cushman, Mary

AU - Ding, Jingzhong

AU - Kritchevsky, Stephen B.

AU - Chaves, Paulo H M

AU - Hirsch, Calvin H.

AU - Newman, Anne B.

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Y1 - 2010/11

N2 - Background. Cross-sectional studies show that adiponectin is higher in older than in younger adults but long-term change in adiponectin, its determinants, and its relationship to functional decline or survival in the elderly population have not been evaluated. Methods. We investigated predictors of longitudinal change in adiponectin, and the association of this adipokine or its antecedent change with physical deterioration and all-cause mortality in 988 participants in a population-based study who completed examinations in 1996-1997 and 2005-2006, had serial adiponectin measurements and underwent follow-up through June 2009. Results. Adiponectin level rose significantly during follow-up, but the increase was smaller in blacks, was associated with declining weight or fasting glucose and, in men, lower albumin, and was affected by medications. Adiponectin was independently associated with greater physical decline, but the relationship for adiponectin change was driven by concomitant weight decrease. Both adiponectin and its change independently predicted mortality, even after adjustment for weight change. The association for adiponectin and mortality was observed in whites but not in blacks and only for levels in the upper range (hazard ratio = 1.85, 95% confidence interval = 1.36-2.52 per SD ≥ 20 mg/L), whereas that for adiponectin change was linear throughout in both racial groups (hazard ratio = 1.30, 95% confidence interval = 1.10-1.52 per SD). Conclusions. Adiponectin levels increase over time in long-lived adults and are associated with greater physical disability and mortality. Such increases may occur in response to age-related homeostatic dysregulation. Additional investigation is required to define the underlying mechanisms and whether this represents a marker or causal factor for mortality in this age group.

AB - Background. Cross-sectional studies show that adiponectin is higher in older than in younger adults but long-term change in adiponectin, its determinants, and its relationship to functional decline or survival in the elderly population have not been evaluated. Methods. We investigated predictors of longitudinal change in adiponectin, and the association of this adipokine or its antecedent change with physical deterioration and all-cause mortality in 988 participants in a population-based study who completed examinations in 1996-1997 and 2005-2006, had serial adiponectin measurements and underwent follow-up through June 2009. Results. Adiponectin level rose significantly during follow-up, but the increase was smaller in blacks, was associated with declining weight or fasting glucose and, in men, lower albumin, and was affected by medications. Adiponectin was independently associated with greater physical decline, but the relationship for adiponectin change was driven by concomitant weight decrease. Both adiponectin and its change independently predicted mortality, even after adjustment for weight change. The association for adiponectin and mortality was observed in whites but not in blacks and only for levels in the upper range (hazard ratio = 1.85, 95% confidence interval = 1.36-2.52 per SD ≥ 20 mg/L), whereas that for adiponectin change was linear throughout in both racial groups (hazard ratio = 1.30, 95% confidence interval = 1.10-1.52 per SD). Conclusions. Adiponectin levels increase over time in long-lived adults and are associated with greater physical disability and mortality. Such increases may occur in response to age-related homeostatic dysregulation. Additional investigation is required to define the underlying mechanisms and whether this represents a marker or causal factor for mortality in this age group.

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KW - Mortality

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