Challenging diagnosis and treatment of HIT in child with ventricular assistance device

Lauren Weintraub, Catherine Driscoll, Scott Aydin, Jacqueline M. Lamour, Samuel Weinstein, Deepa G. Manwani

Research output: Contribution to journalArticle

Abstract

HIT presents the clinician with unique diagnostic challenges, especially in the pediatric population. The HIT clinical sequelae of thrombocytopenia and thrombosis are secondary to the activation of platelets by heparin-antibody complexes. Diagnosis involves clinical observations and confirmatory laboratory testing using antibody detection and the functional SRA. As we describe in the following case of a six-yr-old female, the SRA may be difficult to interpret in the case of high-titer antibodies and illustrates the need for repeat testing in cases of high clinical suspicion.

Original languageEnglish (US)
Pages (from-to)E152-E156
JournalPediatric Transplantation
Volume19
Issue number6
DOIs
StatePublished - Sep 1 2015

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Equipment and Supplies
Antibodies
Platelet Activation
Thrombocytopenia
Heparin
Thrombosis
Therapeutics
Pediatrics
Population

Keywords

  • heparin-induced thrombocytopenia
  • serotonin release assay

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Challenging diagnosis and treatment of HIT in child with ventricular assistance device. / Weintraub, Lauren; Driscoll, Catherine; Aydin, Scott; Lamour, Jacqueline M.; Weinstein, Samuel; Manwani, Deepa G.

In: Pediatric Transplantation, Vol. 19, No. 6, 01.09.2015, p. E152-E156.

Research output: Contribution to journalArticle

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