Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease

Albert K. Luo, Brian K. Jefferson, Mario J. Garcia, Geoffrey S. Ginsburg, Eric J. Topol

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology, which now allows genotyping of hundreds of thousands of single-nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, salient issues to facilitate research in this important field are reviewed.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalJournal of Medical Genetics
Volume44
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Coronary Artery Disease
Research
Single Nucleotide Polymorphism
Myocardial Infarction
Technology
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. / Luo, Albert K.; Jefferson, Brian K.; Garcia, Mario J.; Ginsburg, Geoffrey S.; Topol, Eric J.

In: Journal of Medical Genetics, Vol. 44, No. 3, 03.2007, p. 161-165.

Research output: Contribution to journalArticle

Luo, Albert K. ; Jefferson, Brian K. ; Garcia, Mario J. ; Ginsburg, Geoffrey S. ; Topol, Eric J. / Challenges in the phenotypic characterisation of patients in genetic studies of coronary artery disease. In: Journal of Medical Genetics. 2007 ; Vol. 44, No. 3. pp. 161-165.
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