Chagas disease, adipose tissue and the metabolic syndrome

Fnu Nagajyothi, Mahalia S. Desruisseaux, Louis M. Weiss, Streamson C. Chua, Jr., Chris Albanese, Fabiana S. Machado, Lisia Esper, Michael P. Lisanti, Mauro M. Teixeira, Philipp E. Scherer, Herbert B. Tanowitz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflammatory mediators and a reduction in the expression of the adipokine adiponectin. T. cruzi can be detected in adipose tissue by PCR 300 days post-infection. Infection of cultured adipocytes results in increased expression of cytokines and chemokines and a reduction in the expression of adiponectin and the peroxisome proliferator-activated receptor γ, both of which are negative regulators of inflammation. Infection also results in the upregulation of cyclin D1, the Notch pathway, and extracellular signal-regulated kinase and a reduction in the expression of caveolin-1. Thus, T. cruzi infection of cultured adipocytes leads to an upregulation of the inflammatory process. Since adiponectin null mice have a cardiomyopathic phenotype, it is possible that the reduction in adiponectin contributes to the pathogenesis of chagasic cardiomyopathy. Adipose tissue may serve as a reservoir for T. cruzi from which parasites can become reactivated during periods of immunosuppression. T. cruzi infection of mice often results in hypoglycemia. In contrast, hyperglycemia as observed in diabetes results in increased parasitemia and mortality. Adipose tissue is an important target tissue of T. cruzi and the infection of this tissue is associated with a profound impact on systemic metabolism, increasing the risk of metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalMemorias do Instituto Oswaldo Cruz
Volume104
Issue numberSUPPL. 1
StatePublished - Jul 2009

Fingerprint

Chagas Disease
Trypanosoma cruzi
Adipose Tissue
Infection
Adiponectin
Adipocytes
Up-Regulation
Caveolin 1
Peroxisome Proliferator-Activated Receptors
Adipokines
Parasitemia
Cyclin D1
Extracellular Signal-Regulated MAP Kinases
Cardiomyopathies
Chemokines
Hypoglycemia
Hyperglycemia
Immunosuppression
Parasites
Cytokines

Keywords

  • Adipocyte
  • Adiponectin
  • Adipose tissue
  • Chagas disease
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Nagajyothi, F., Desruisseaux, M. S., Weiss, L. M., Chua, Jr., S. C., Albanese, C., Machado, F. S., ... Tanowitz, H. B. (2009). Chagas disease, adipose tissue and the metabolic syndrome. Memorias do Instituto Oswaldo Cruz, 104(SUPPL. 1), 219-225.

Chagas disease, adipose tissue and the metabolic syndrome. / Nagajyothi, Fnu; Desruisseaux, Mahalia S.; Weiss, Louis M.; Chua, Jr., Streamson C.; Albanese, Chris; Machado, Fabiana S.; Esper, Lisia; Lisanti, Michael P.; Teixeira, Mauro M.; Scherer, Philipp E.; Tanowitz, Herbert B.

In: Memorias do Instituto Oswaldo Cruz, Vol. 104, No. SUPPL. 1, 07.2009, p. 219-225.

Research output: Contribution to journalArticle

Nagajyothi, F, Desruisseaux, MS, Weiss, LM, Chua, Jr., SC, Albanese, C, Machado, FS, Esper, L, Lisanti, MP, Teixeira, MM, Scherer, PE & Tanowitz, HB 2009, 'Chagas disease, adipose tissue and the metabolic syndrome', Memorias do Instituto Oswaldo Cruz, vol. 104, no. SUPPL. 1, pp. 219-225.
Nagajyothi F, Desruisseaux MS, Weiss LM, Chua, Jr. SC, Albanese C, Machado FS et al. Chagas disease, adipose tissue and the metabolic syndrome. Memorias do Instituto Oswaldo Cruz. 2009 Jul;104(SUPPL. 1):219-225.
Nagajyothi, Fnu ; Desruisseaux, Mahalia S. ; Weiss, Louis M. ; Chua, Jr., Streamson C. ; Albanese, Chris ; Machado, Fabiana S. ; Esper, Lisia ; Lisanti, Michael P. ; Teixeira, Mauro M. ; Scherer, Philipp E. ; Tanowitz, Herbert B. / Chagas disease, adipose tissue and the metabolic syndrome. In: Memorias do Instituto Oswaldo Cruz. 2009 ; Vol. 104, No. SUPPL. 1. pp. 219-225.
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