Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation

Mohak Mhatre, Thomas McAndrew, Colleen Carpenter, Robert D. Burk, Mark H. Einstein, Betsy Herold

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND: Clinical studies demonstrate increased prevalence of human papillomavirus (HPV)-associated disease in HIV-infected individuals and an increased risk of HIV acquisition in HPV-infected individuals. The mechanisms underlying this synergy are not defined. We hypothesize that women with cervical intraepithelial neoplasia (CIN) will exhibit changes in soluble mucosal immunity that may promote HPV persistence and facilitate HIV infection. METHODS: The concentrations of immune mediators and endogenous anti-Escherichia coli activity in genital tract secretions collected by cervicovaginal lavage were compared in HIV-negative women with high-risk HPV-positive (HRHPV+) CIN-3 (n = 37), HRHPV+ CIN-1 (n = 12), or PAP-negative control subjects (n = 57). RESULTS: Compared with control subjects, women with CIN-3 or CIN-1 displayed significantly higher levels of proinflammatory cytokines including interleukin (IL)-1α, IL-1β, and IL-8 (P < 0.002) and significantly lower levels of anti-inflammatory mediators and antimicrobial peptides, including IL-1 receptor antagonist, secretory leukocyte protease inhibitor (P < 0.01), and human β defensins 2 and 3 (P < 0.02). There was no significant difference in endogenous anti-E. coli activity after controlling for age and sample storage time. CONCLUSION: HRHPV+ CIN is characterized by changes in soluble mucosal immunity that could contribute to HPV persistence. The observed mucosal inflammation suggests a mechanism that may also contribute to the epidemiologic link between persistent HPV and HIV.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalSexually Transmitted Diseases
Volume39
Issue number8
DOIs
StatePublished - Aug 2012

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Cervical Intraepithelial Neoplasia
Inflammation
HIV
Mucosal Immunity
Interleukin-1
Secretory Leukocyte Peptidase Inhibitor
Escherichia coli
Defensins
Interleukin-1 Receptors
Therapeutic Irrigation
Interleukin-8
HIV Infections
Anti-Inflammatory Agents
Cytokines
Peptides

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation. / Mhatre, Mohak; McAndrew, Thomas; Carpenter, Colleen; Burk, Robert D.; Einstein, Mark H.; Herold, Betsy.

In: Sexually Transmitted Diseases, Vol. 39, No. 8, 08.2012, p. 591-597.

Research output: Contribution to journalArticle

Mhatre, Mohak ; McAndrew, Thomas ; Carpenter, Colleen ; Burk, Robert D. ; Einstein, Mark H. ; Herold, Betsy. / Cervical intraepithelial neoplasia is associated with genital tract mucosal inflammation. In: Sexually Transmitted Diseases. 2012 ; Vol. 39, No. 8. pp. 591-597.
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