Cervical human papillomavirus detection is not affected by menstrual phase

Joseph E. Tota, Agnihotram V. Ramanakumar, Salaheddin M. Mahmud, Andrea Trevisan, Luisa L. Villa, Eduardo L. Franco, Maria Luiza Baggio, Lenice Galan, João Simão Sobrinho, José Carlos Mann Prado, Silvaneide Ferreira, Lara Termini, Maria Cecília Costa, Romulo Miyamura, Patricia Thomann, João Candeias, Laura Sichero, Paula Rahal, Antonio Ruiz, Jane Kaiano & 14 others Monica Santos, Patricia Savio, Paulo Maciag, Tatiana Rabachini, Marie Claude Rousseau, Nicolas Schlecht, Helen Trottier, Alex Ferenczy, Thomas E. Rohan, Myriam Chevarie-Davis, Eliane Duarte, Sophie Kulaga, Juliette Robitaille, Robert Platt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: In many settings, human papillomavirus (HPV) DNA testing already plays an important role in cervical cancer screening. It is unclear whether hormonal fl uctuations associated with menstrual phase or oral contraceptive (OC) use have any effect on HPV detection. We evaluated the effects of OC use and timing of cervical sampling in relation to women' s last menstrual period (LMP) on HPV detection, and viral load in the Brazilian Ludwig - McGill cohort study. Methods: Women in the cohort were followed every 4-6 months, and at each clinic visit they were asked to complete a questionnaire and to provide a cervical sample for HPV testing. Specimens from 6093 patient visits (n=2209 women) were categorised according to date of LMP into four distinct phases: follicular (days 5-9), midcycle (days 10-15), luteal (days 16-22), or late luteal (days 23-31). Results: Compared with follicular phase (referent group), HPV detection did not differ according to reported LMP for midcycle (OR=1.14, 95% CI 0.95 to 1.37), luteal (OR=1.03, 95% CI 0.85 to 1.25), or late luteal menstrual phase (OR=1.01, 95% CI 0.83 to 1.24), and was also not influenced by OC use. Analyses restricted to high-risk HPV types (grouped) and HPVs 16 and 18 (separately), produced similar non-signi fi cant associations. For HPV-positive samples, we found that the menstrual phase did not influence the total viral load. Conclusions: These results indicate HPV detection is not associated with menstrual phase. Our findings suggest that standardising the timing of specimen collection for HPV testing is not necessary.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalSexually Transmitted Infections
Volume89
Issue number3
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Corpus Luteum
Oral Contraceptives
Follicular Phase
Human papillomavirus 16
Viral Load
Specimen Handling
Human papillomavirus 18
Luteal Phase
Ambulatory Care
Early Detection of Cancer
Uterine Cervical Neoplasms
Cohort Studies
DNA

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Tota, J. E., Ramanakumar, A. V., Mahmud, S. M., Trevisan, A., Villa, L. L., Franco, E. L., ... Platt, R. (2013). Cervical human papillomavirus detection is not affected by menstrual phase. Sexually Transmitted Infections, 89(3), 202-206. https://doi.org/10.1136/sextrans-2012-050610

Cervical human papillomavirus detection is not affected by menstrual phase. / Tota, Joseph E.; Ramanakumar, Agnihotram V.; Mahmud, Salaheddin M.; Trevisan, Andrea; Villa, Luisa L.; Franco, Eduardo L.; Baggio, Maria Luiza; Galan, Lenice; Sobrinho, João Simão; Prado, José Carlos Mann; Ferreira, Silvaneide; Termini, Lara; Costa, Maria Cecília; Miyamura, Romulo; Thomann, Patricia; Candeias, João; Sichero, Laura; Rahal, Paula; Ruiz, Antonio; Kaiano, Jane; Santos, Monica; Savio, Patricia; Maciag, Paulo; Rabachini, Tatiana; Rousseau, Marie Claude; Schlecht, Nicolas; Trottier, Helen; Ferenczy, Alex; Rohan, Thomas E.; Chevarie-Davis, Myriam; Duarte, Eliane; Kulaga, Sophie; Robitaille, Juliette; Platt, Robert.

In: Sexually Transmitted Infections, Vol. 89, No. 3, 05.2013, p. 202-206.

Research output: Contribution to journalArticle

Tota, JE, Ramanakumar, AV, Mahmud, SM, Trevisan, A, Villa, LL, Franco, EL, Baggio, ML, Galan, L, Sobrinho, JS, Prado, JCM, Ferreira, S, Termini, L, Costa, MC, Miyamura, R, Thomann, P, Candeias, J, Sichero, L, Rahal, P, Ruiz, A, Kaiano, J, Santos, M, Savio, P, Maciag, P, Rabachini, T, Rousseau, MC, Schlecht, N, Trottier, H, Ferenczy, A, Rohan, TE, Chevarie-Davis, M, Duarte, E, Kulaga, S, Robitaille, J & Platt, R 2013, 'Cervical human papillomavirus detection is not affected by menstrual phase', Sexually Transmitted Infections, vol. 89, no. 3, pp. 202-206. https://doi.org/10.1136/sextrans-2012-050610
Tota JE, Ramanakumar AV, Mahmud SM, Trevisan A, Villa LL, Franco EL et al. Cervical human papillomavirus detection is not affected by menstrual phase. Sexually Transmitted Infections. 2013 May;89(3):202-206. https://doi.org/10.1136/sextrans-2012-050610
Tota, Joseph E. ; Ramanakumar, Agnihotram V. ; Mahmud, Salaheddin M. ; Trevisan, Andrea ; Villa, Luisa L. ; Franco, Eduardo L. ; Baggio, Maria Luiza ; Galan, Lenice ; Sobrinho, João Simão ; Prado, José Carlos Mann ; Ferreira, Silvaneide ; Termini, Lara ; Costa, Maria Cecília ; Miyamura, Romulo ; Thomann, Patricia ; Candeias, João ; Sichero, Laura ; Rahal, Paula ; Ruiz, Antonio ; Kaiano, Jane ; Santos, Monica ; Savio, Patricia ; Maciag, Paulo ; Rabachini, Tatiana ; Rousseau, Marie Claude ; Schlecht, Nicolas ; Trottier, Helen ; Ferenczy, Alex ; Rohan, Thomas E. ; Chevarie-Davis, Myriam ; Duarte, Eliane ; Kulaga, Sophie ; Robitaille, Juliette ; Platt, Robert. / Cervical human papillomavirus detection is not affected by menstrual phase. In: Sexually Transmitted Infections. 2013 ; Vol. 89, No. 3. pp. 202-206.
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abstract = "Objectives: In many settings, human papillomavirus (HPV) DNA testing already plays an important role in cervical cancer screening. It is unclear whether hormonal fl uctuations associated with menstrual phase or oral contraceptive (OC) use have any effect on HPV detection. We evaluated the effects of OC use and timing of cervical sampling in relation to women' s last menstrual period (LMP) on HPV detection, and viral load in the Brazilian Ludwig - McGill cohort study. Methods: Women in the cohort were followed every 4-6 months, and at each clinic visit they were asked to complete a questionnaire and to provide a cervical sample for HPV testing. Specimens from 6093 patient visits (n=2209 women) were categorised according to date of LMP into four distinct phases: follicular (days 5-9), midcycle (days 10-15), luteal (days 16-22), or late luteal (days 23-31). Results: Compared with follicular phase (referent group), HPV detection did not differ according to reported LMP for midcycle (OR=1.14, 95{\%} CI 0.95 to 1.37), luteal (OR=1.03, 95{\%} CI 0.85 to 1.25), or late luteal menstrual phase (OR=1.01, 95{\%} CI 0.83 to 1.24), and was also not influenced by OC use. Analyses restricted to high-risk HPV types (grouped) and HPVs 16 and 18 (separately), produced similar non-signi fi cant associations. For HPV-positive samples, we found that the menstrual phase did not influence the total viral load. Conclusions: These results indicate HPV detection is not associated with menstrual phase. Our findings suggest that standardising the timing of specimen collection for HPV testing is not necessary.",
author = "Tota, {Joseph E.} and Ramanakumar, {Agnihotram V.} and Mahmud, {Salaheddin M.} and Andrea Trevisan and Villa, {Luisa L.} and Franco, {Eduardo L.} and Baggio, {Maria Luiza} and Lenice Galan and Sobrinho, {Jo{\~a}o Sim{\~a}o} and Prado, {Jos{\'e} Carlos Mann} and Silvaneide Ferreira and Lara Termini and Costa, {Maria Cec{\'i}lia} and Romulo Miyamura and Patricia Thomann and Jo{\~a}o Candeias and Laura Sichero and Paula Rahal and Antonio Ruiz and Jane Kaiano and Monica Santos and Patricia Savio and Paulo Maciag and Tatiana Rabachini and Rousseau, {Marie Claude} and Nicolas Schlecht and Helen Trottier and Alex Ferenczy and Rohan, {Thomas E.} and Myriam Chevarie-Davis and Eliane Duarte and Sophie Kulaga and Juliette Robitaille and Robert Platt",
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T1 - Cervical human papillomavirus detection is not affected by menstrual phase

AU - Tota, Joseph E.

AU - Ramanakumar, Agnihotram V.

AU - Mahmud, Salaheddin M.

AU - Trevisan, Andrea

AU - Villa, Luisa L.

AU - Franco, Eduardo L.

AU - Baggio, Maria Luiza

AU - Galan, Lenice

AU - Sobrinho, João Simão

AU - Prado, José Carlos Mann

AU - Ferreira, Silvaneide

AU - Termini, Lara

AU - Costa, Maria Cecília

AU - Miyamura, Romulo

AU - Thomann, Patricia

AU - Candeias, João

AU - Sichero, Laura

AU - Rahal, Paula

AU - Ruiz, Antonio

AU - Kaiano, Jane

AU - Santos, Monica

AU - Savio, Patricia

AU - Maciag, Paulo

AU - Rabachini, Tatiana

AU - Rousseau, Marie Claude

AU - Schlecht, Nicolas

AU - Trottier, Helen

AU - Ferenczy, Alex

AU - Rohan, Thomas E.

AU - Chevarie-Davis, Myriam

AU - Duarte, Eliane

AU - Kulaga, Sophie

AU - Robitaille, Juliette

AU - Platt, Robert

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N2 - Objectives: In many settings, human papillomavirus (HPV) DNA testing already plays an important role in cervical cancer screening. It is unclear whether hormonal fl uctuations associated with menstrual phase or oral contraceptive (OC) use have any effect on HPV detection. We evaluated the effects of OC use and timing of cervical sampling in relation to women' s last menstrual period (LMP) on HPV detection, and viral load in the Brazilian Ludwig - McGill cohort study. Methods: Women in the cohort were followed every 4-6 months, and at each clinic visit they were asked to complete a questionnaire and to provide a cervical sample for HPV testing. Specimens from 6093 patient visits (n=2209 women) were categorised according to date of LMP into four distinct phases: follicular (days 5-9), midcycle (days 10-15), luteal (days 16-22), or late luteal (days 23-31). Results: Compared with follicular phase (referent group), HPV detection did not differ according to reported LMP for midcycle (OR=1.14, 95% CI 0.95 to 1.37), luteal (OR=1.03, 95% CI 0.85 to 1.25), or late luteal menstrual phase (OR=1.01, 95% CI 0.83 to 1.24), and was also not influenced by OC use. Analyses restricted to high-risk HPV types (grouped) and HPVs 16 and 18 (separately), produced similar non-signi fi cant associations. For HPV-positive samples, we found that the menstrual phase did not influence the total viral load. Conclusions: These results indicate HPV detection is not associated with menstrual phase. Our findings suggest that standardising the timing of specimen collection for HPV testing is not necessary.

AB - Objectives: In many settings, human papillomavirus (HPV) DNA testing already plays an important role in cervical cancer screening. It is unclear whether hormonal fl uctuations associated with menstrual phase or oral contraceptive (OC) use have any effect on HPV detection. We evaluated the effects of OC use and timing of cervical sampling in relation to women' s last menstrual period (LMP) on HPV detection, and viral load in the Brazilian Ludwig - McGill cohort study. Methods: Women in the cohort were followed every 4-6 months, and at each clinic visit they were asked to complete a questionnaire and to provide a cervical sample for HPV testing. Specimens from 6093 patient visits (n=2209 women) were categorised according to date of LMP into four distinct phases: follicular (days 5-9), midcycle (days 10-15), luteal (days 16-22), or late luteal (days 23-31). Results: Compared with follicular phase (referent group), HPV detection did not differ according to reported LMP for midcycle (OR=1.14, 95% CI 0.95 to 1.37), luteal (OR=1.03, 95% CI 0.85 to 1.25), or late luteal menstrual phase (OR=1.01, 95% CI 0.83 to 1.24), and was also not influenced by OC use. Analyses restricted to high-risk HPV types (grouped) and HPVs 16 and 18 (separately), produced similar non-signi fi cant associations. For HPV-positive samples, we found that the menstrual phase did not influence the total viral load. Conclusions: These results indicate HPV detection is not associated with menstrual phase. Our findings suggest that standardising the timing of specimen collection for HPV testing is not necessary.

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