Cerebral malaria: We have come a long way

Henry J. Shikani, Brandi D. Freeman, Michael P. Lisanti, Louis M. Weiss, Herbert B. Tanowitz, Mahalia S. Desruisseaux

Research output: Contribution to journalReview article

45 Scopus citations


Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.

Original languageEnglish (US)
Pages (from-to)1484-1492
Number of pages9
JournalAmerican Journal of Pathology
Issue number5
StatePublished - Nov 2012


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Shikani, H. J., Freeman, B. D., Lisanti, M. P., Weiss, L. M., Tanowitz, H. B., & Desruisseaux, M. S. (2012). Cerebral malaria: We have come a long way. American Journal of Pathology, 181(5), 1484-1492. https://doi.org/10.1016/j.ajpath.2012.08.010