Cerebral malaria

We have come a long way

Henry J. Shikani, Brandi D. Freeman, Michael P. Lisanti, Louis M. Weiss, Herbert B. Tanowitz, Mahalia S. Desruisseaux

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.

Original languageEnglish (US)
Pages (from-to)1484-1492
Number of pages9
JournalAmerican Journal of Pathology
Volume181
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Cerebral Malaria
Antiparasitic Agents
Africa South of the Sahara
Research
Malaria
Survivors
Theoretical Models
Pathology
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Shikani, H. J., Freeman, B. D., Lisanti, M. P., Weiss, L. M., Tanowitz, H. B., & Desruisseaux, M. S. (2012). Cerebral malaria: We have come a long way. American Journal of Pathology, 181(5), 1484-1492. https://doi.org/10.1016/j.ajpath.2012.08.010

Cerebral malaria : We have come a long way. / Shikani, Henry J.; Freeman, Brandi D.; Lisanti, Michael P.; Weiss, Louis M.; Tanowitz, Herbert B.; Desruisseaux, Mahalia S.

In: American Journal of Pathology, Vol. 181, No. 5, 11.2012, p. 1484-1492.

Research output: Contribution to journalArticle

Shikani, HJ, Freeman, BD, Lisanti, MP, Weiss, LM, Tanowitz, HB & Desruisseaux, MS 2012, 'Cerebral malaria: We have come a long way', American Journal of Pathology, vol. 181, no. 5, pp. 1484-1492. https://doi.org/10.1016/j.ajpath.2012.08.010
Shikani HJ, Freeman BD, Lisanti MP, Weiss LM, Tanowitz HB, Desruisseaux MS. Cerebral malaria: We have come a long way. American Journal of Pathology. 2012 Nov;181(5):1484-1492. https://doi.org/10.1016/j.ajpath.2012.08.010
Shikani, Henry J. ; Freeman, Brandi D. ; Lisanti, Michael P. ; Weiss, Louis M. ; Tanowitz, Herbert B. ; Desruisseaux, Mahalia S. / Cerebral malaria : We have come a long way. In: American Journal of Pathology. 2012 ; Vol. 181, No. 5. pp. 1484-1492.
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