Cerebral germinomas and klinefelter syndrome. A review

Raanan Arens, Daniel Marcus, Santiago Engelberg, Gideon Findler, Richard M. Goodman, Justen H. Passwell

Research output: Contribution to journalArticle

34 Scopus citations


Patients with Klinefelter syndrome appear to be predisposed to the development of extragonadal cerebral germinomas. A case of a pineal region germinoma in a boy 15 years of age with Klinefelter syndrome is documented in this article. In view of three other cases of cerebral germinomas associated with Klinefelter syndrome in the literature, a hypothesis for this predisposition is suggested.

Original languageEnglish (US)
Pages (from-to)1228-1231
Number of pages4
Issue number6
StatePublished - Mar 15 1988
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Arens, R., Marcus, D., Engelberg, S., Findler, G., Goodman, R. M., & Passwell, J. H. (1988). Cerebral germinomas and klinefelter syndrome. A review. Cancer, 61(6), 1228-1231. https://doi.org/10.1002/1097-0142(19880315)61:6<1228::AID-CNCR2820610628>3.0.CO;2-R