Cellular responses in human strongyloidiasis

R. M. Genta, E. A. Ottesen, F. A. Neva, P. D. Walzer, H. B. Tanowitz, M. Wittner

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Peripheral lymphocytes from 16 patients with chronic uncomplicated strongyloidiasis and 15 non-infected controls were stimulated in vitro with Strongyloides stercoralis larval antigens, other non-parasite antigens and the T cell mitogen phytohemagglutinin (PHA). In the presence of autologous plasma the patients' responses to Strongyloides antigens were similar to those of controls. When lymphocytes from nine patients were cultured in the presence of normal human serum, responses to parasite antigens were enhanced, while responses to other antigens and to PHA were unaffected. Lymphoproliferative responses to PHA were significantly lower in the patients' group than in the controls. These findings suggest that in chronic strongyloidiasis, in addition to a depression of T cell activity, factors are present in the patients' serum that inhibit parasite-specific cellular responses in vitro.

Original languageEnglish (US)
Pages (from-to)990-994
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume32
Issue number5
StatePublished - 1983
Externally publishedYes

Fingerprint

Strongyloidiasis
Antigens
Phytohemagglutinins
Parasites
Strongyloides
Lymphocytes
Strongyloides stercoralis
TCF Transcription Factors
Serum
Mitogens
T-Lymphocytes
Control Groups

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Genta, R. M., Ottesen, E. A., Neva, F. A., Walzer, P. D., Tanowitz, H. B., & Wittner, M. (1983). Cellular responses in human strongyloidiasis. American Journal of Tropical Medicine and Hygiene, 32(5), 990-994.

Cellular responses in human strongyloidiasis. / Genta, R. M.; Ottesen, E. A.; Neva, F. A.; Walzer, P. D.; Tanowitz, H. B.; Wittner, M.

In: American Journal of Tropical Medicine and Hygiene, Vol. 32, No. 5, 1983, p. 990-994.

Research output: Contribution to journalArticle

Genta, RM, Ottesen, EA, Neva, FA, Walzer, PD, Tanowitz, HB & Wittner, M 1983, 'Cellular responses in human strongyloidiasis', American Journal of Tropical Medicine and Hygiene, vol. 32, no. 5, pp. 990-994.
Genta RM, Ottesen EA, Neva FA, Walzer PD, Tanowitz HB, Wittner M. Cellular responses in human strongyloidiasis. American Journal of Tropical Medicine and Hygiene. 1983;32(5):990-994.
Genta, R. M. ; Ottesen, E. A. ; Neva, F. A. ; Walzer, P. D. ; Tanowitz, H. B. ; Wittner, M. / Cellular responses in human strongyloidiasis. In: American Journal of Tropical Medicine and Hygiene. 1983 ; Vol. 32, No. 5. pp. 990-994.
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