Cellular responses in human strongyloidiasis

R. M. Genta, E. A. Ottesen, F. A. Neva, P. D. Walzer, H. B. Tanowitz, M. Wittner

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Peripheral lymphocytes from 16 patients with chronic uncomplicated strongyloidiasis and 15 non-infected controls were stimulated in vitro with Strongyloides stercoralis larval antigens, other non-parasite antigens and the T cell mitogen phytohemagglutinin (PHA). In the presence of autologous plasma the patients' responses to Strongyloides antigens were similar to those of controls. When lymphocytes from nine patients were cultured in the presence of normal human serum, responses to parasite antigens were enhanced, while responses to other antigens and to PHA were unaffected. Lymphoproliferative responses to PHA were significantly lower in the patients' group than in the controls. These findings suggest that in chronic strongyloidiasis, in addition to a depression of T cell activity, factors are present in the patients' serum that inhibit parasite-specific cellular responses in vitro.

Original languageEnglish (US)
Pages (from-to)990-994
Number of pages5
JournalUnknown Journal
Volume32
Issue number5
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Cellular responses in human strongyloidiasis'. Together they form a unique fingerprint.

  • Cite this

    Genta, R. M., Ottesen, E. A., Neva, F. A., Walzer, P. D., Tanowitz, H. B., & Wittner, M. (1983). Cellular responses in human strongyloidiasis. Unknown Journal, 32(5), 990-994. https://doi.org/10.4269/ajtmh.1983.32.990