Cellular generators of the cortical auditory evoked potential initial component

Mitchell Steinschneider, Craig E. Tenke, Charles E. Schroeder, Daniel C. Javitt, Gregory V. Simpson, Joseph C. Arezzo, Herbert G. Vaughan

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Cellular generators of the initial auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume84
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • Auditory cortex
  • Cellular generators
  • Current source density
  • Evoked potential
  • Multiple unit activity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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