Cell type-specific pharmacology of NMDA receptors using masked MK801

Yunlei Yang, Peter Lee, Scott M. Sternson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.

Original languageEnglish (US)
Article numbere10206
JournaleLife
Volume4
Issue numberSeptember 2015
DOIs
StatePublished - Sep 11 2015

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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