Cell type-specific pharmacology of NMDA receptors using masked MK801

Yunlei Yang, Peter Lee, Scott M. Sternson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

N-Methyl-D-aspartate receptors (NMDA-Rs) are ion channels that are important for synaptic plasticity, which is involved in learning and drug addiction. We show enzymatic targeting of an NMDA-R antagonist, MK801, to a molecularly defined neuronal population with the cell-type-selectivity of genetic methods and the temporal control of pharmacology. We find that NMDA-Rs on dopamine neurons are necessary for cocaine-induced synaptic potentiation, demonstrating that cell type-specific pharmacology can be used to dissect signaling pathways within complex brain circuits.

Original languageEnglish (US)
Article numbere10206
JournaleLife
Volume4
Issue numberSeptember 2015
DOIs
StatePublished - Sep 11 2015
Externally publishedYes

Fingerprint

N-Methyl-D-Aspartate Receptors
Pharmacology
Neuronal Plasticity
Dopaminergic Neurons
N-Methylaspartate
Ion Channels
Cocaine
Neurons
Substance-Related Disorders
Plasticity
Dopamine
Brain
Learning
Networks (circuits)
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Cell type-specific pharmacology of NMDA receptors using masked MK801. / Yang, Yunlei; Lee, Peter; Sternson, Scott M.

In: eLife, Vol. 4, No. September 2015, e10206, 11.09.2015.

Research output: Contribution to journalArticle

Yang, Yunlei ; Lee, Peter ; Sternson, Scott M. / Cell type-specific pharmacology of NMDA receptors using masked MK801. In: eLife. 2015 ; Vol. 4, No. September 2015.
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