Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

Lucas L. Sjulson, Daniela Cassataro, Shamik Dasgupta, Gero Miesenböck

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Genetically encoded tools for visualizing and manipulating neurons in vivo have led to significant advances in neuroscience, in large part because of the ability to target expression to specific cell populations of interest. Current methods enable targeting based on marker gene expression, development, anatomical projection pattern, synaptic connectivity, and recent activity as well as combinations of these factors. Here, we review these methods, focusing on issues of practical implementation as well as areas for future improvement.

Original languageEnglish (US)
Pages (from-to)571-594
Number of pages24
JournalAnnual Review of Genetics
Volume50
DOIs
Publication statusPublished - Nov 23 2016
Externally publishedYes

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Keywords

  • Actuator
  • Chemogenetics
  • Effector
  • Optogenetics
  • Reporter
  • Transgene expression
  • Viral vector

ASJC Scopus subject areas

  • Genetics

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