Cell proliferation, survival, and death in the Drosophila eye

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

The Drosophila retina has a precise repeating structure based on the unit eye, or ommatidium. This review summarizes studies of the cell proliferation and survival episodes that affect the number of cells available to make each ommatidium. Late in larval development, as differentiation and patterning begin, the retinal epithelium exhibits striking regulation of the cell cycle including a transient G1 arrest of all cells, followed by a 'Second Mitotic Wave' cell cycle that is regulated at the G2/M transition by local intercellular signals. Reiterated episodes of cell death also contribute to precise regulation of retinal cell number. The EGF receptor homolog has multiple roles in retinal proliferation and survival.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume12
Issue number6
DOIs
StatePublished - Jan 1 2001

Keywords

  • Apoptosis
  • Drosophila
  • Proliferation
  • Survival

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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