C/EBPβ suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL

William T. Choi, Matthew R. Folsom, Mohammed F. Azim, Claus Meyer, Eric Kowarz, Rolf Marschalek, Nikolai A. Timchenko, Rizwan C. Naeem, Dean A. Lee

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Translocations involving the mixed-lineage leukemia gene (MLL) confer a poor prognosis in acute leukemias. In t(1;11)(q21;q23), MLL is fused reciprocally with AF1q. Here we describe a t(1;11)(q21;q23) with a secondary event involving insertion of the telomeric portion of MLL into the p arm of chromosome 11 (11p11). We show that this latter event interrupts the CUG triplet repeat binding protein-1 (CUGBP1) gene, a translational enhancer of C/EBPβ. We then showed that these cells have reduced expression of CUGBP1 and C/EBPβ when compared to other AML blasts. This is the first report to describe insertional disruption of the CUGBP1 gene and to suggest a role for the CUGBP1-C/EBPβ pathway in leukemogenesis.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume177
Issue number2
DOIs
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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