CCR5 expression levels in HIV-uninfected women receiving hormonal contraception

Gaia Sciaranghella, Cuiwei Wang, Haihong Hu, Kathryn Anastos, Zaher Merhi, Marek Nowicki, Frank Z. Stanczyk, Ruth M. Greenblatt, Mardge Cohen, Elizabeth T. Golub, D. Heather Watts, Galit Alter, Mary A. Young, Athe M.N. Tsibris

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4+ and CD8+ T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P <. 01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.

Original languageEnglish (US)
Pages (from-to)1397-1401
Number of pages5
JournalJournal of Infectious Diseases
Volume212
Issue number9
DOIs
StatePublished - Nov 1 2015

Keywords

  • CCR5
  • CD4
  • CXCR4
  • HIV-1
  • hormonal contraception
  • levonorgestrel
  • medroxyprogesterone acetate
  • oral contraceptive pills
  • peripheral blood mononuclear cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'CCR5 expression levels in HIV-uninfected women receiving hormonal contraception'. Together they form a unique fingerprint.

Cite this