Catechol O-Methyltransferase Val158Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility

Karen A. Nolan, Robert M. Bilder, Herbert M. Lachman, Jan Volavka

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Objective: The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively. Method: Twenty-six patients with schizophrenia and schizoaffective disorder completed a task requiring alternation between imitation and reversal rules. Results: Met homozygotes showed better acquisition of the imitation rule but greater deficit shifting from imitation to reversal. Val homozygotes had poorer imitation performance and slower reaction times. Conclusions: The Met allele, by increasing tonic dopamine, may promote cognitive stability but limit cognitive flexibility.

Original languageEnglish (US)
Pages (from-to)359-361
Number of pages3
JournalAmerican Journal of Psychiatry
Volume161
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Catechol O-Methyltransferase
Reversal Learning
Schizophrenia
Alleles
Homozygote
Genotype
Phenotype
Psychotic Disorders
Reaction Time
Dopamine
Learning

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Catechol O-Methyltransferase Val158Met Polymorphism in Schizophrenia : Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility. / Nolan, Karen A.; Bilder, Robert M.; Lachman, Herbert M.; Volavka, Jan.

In: American Journal of Psychiatry, Vol. 161, No. 2, 02.2004, p. 359-361.

Research output: Contribution to journalArticle

@article{f98d5bcf974b4606a0f6b71bc401dee2,
title = "Catechol O-Methyltransferase Val158Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility",
abstract = "Objective: The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively. Method: Twenty-six patients with schizophrenia and schizoaffective disorder completed a task requiring alternation between imitation and reversal rules. Results: Met homozygotes showed better acquisition of the imitation rule but greater deficit shifting from imitation to reversal. Val homozygotes had poorer imitation performance and slower reaction times. Conclusions: The Met allele, by increasing tonic dopamine, may promote cognitive stability but limit cognitive flexibility.",
author = "Nolan, {Karen A.} and Bilder, {Robert M.} and Lachman, {Herbert M.} and Jan Volavka",
year = "2004",
month = "2",
doi = "10.1176/appi.ajp.161.2.359",
language = "English (US)",
volume = "161",
pages = "359--361",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "2",

}

TY - JOUR

T1 - Catechol O-Methyltransferase Val158Met Polymorphism in Schizophrenia

T2 - Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility

AU - Nolan, Karen A.

AU - Bilder, Robert M.

AU - Lachman, Herbert M.

AU - Volavka, Jan

PY - 2004/2

Y1 - 2004/2

N2 - Objective: The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively. Method: Twenty-six patients with schizophrenia and schizoaffective disorder completed a task requiring alternation between imitation and reversal rules. Results: Met homozygotes showed better acquisition of the imitation rule but greater deficit shifting from imitation to reversal. Val homozygotes had poorer imitation performance and slower reaction times. Conclusions: The Met allele, by increasing tonic dopamine, may promote cognitive stability but limit cognitive flexibility.

AB - Objective: The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively. Method: Twenty-six patients with schizophrenia and schizoaffective disorder completed a task requiring alternation between imitation and reversal rules. Results: Met homozygotes showed better acquisition of the imitation rule but greater deficit shifting from imitation to reversal. Val homozygotes had poorer imitation performance and slower reaction times. Conclusions: The Met allele, by increasing tonic dopamine, may promote cognitive stability but limit cognitive flexibility.

UR - http://www.scopus.com/inward/record.url?scp=1642446036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642446036&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.161.2.359

DO - 10.1176/appi.ajp.161.2.359

M3 - Article

C2 - 14754787

AN - SCOPUS:1642446036

VL - 161

SP - 359

EP - 361

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 2

ER -