Cases in precision medicine: APOL1 and genetic testing in the evaluation of chronic kidney disease and potential transplant

Y. Dana Neugut; Sumit Mohan; Ali G. Gharavi; Krzysztof Kiryluk

doi:10.7326/M19-1389

Cases in precision medicine: APOL1 and genetic testing in the evaluation of chronic kidney disease and potential transplant

Y. Dana Neugut, Sumit Mohan, Ali G. Gharavi, Krzysztof Kiryluk

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, The role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.

Original language	English (US)
Pages (from-to)	659-664
Number of pages	6
Journal	Annals of internal medicine
Volume	171
Issue number	9
DOIs	https://doi.org/10.7326/M19-1389
State	Published - Nov 5 2019
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

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abstract = "This article discusses potential indications for genetic testing in an African American patient with chronic kidney disease who is being evaluated for a kidney transplant. Two known risk variants in the APOL1 (apolipoprotein L1) gene predispose to kidney disease and are found almost exclusively in persons of African ancestry. APOL1 risk variants are considered, including whether clinicians should incorporate genetic testing in the screening process for living kidney donors. In addition to APOL1 testing, The role of diagnostic exome sequencing in evaluating potential transplant recipients and donors with a positive family history of kidney disease is discussed.",

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Cases in precision medicine: APOL1 and genetic testing in the evaluation of chronic kidney disease and potential transplant

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