Case report: Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis

Manish Nepal, Roshan Mainali, Charles M. Schworer, William Difilippo, Ping L. Zhang, Michael F. Schultz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The nephrotic range of proteinuria is uncommon in scleroderma renal crisis. This 46-yr-old woman with a medical history of scleroderma presented with very high blood pressure, a sudden elevation of serum creatinine, and proteinuria in the nephrotic range. Renal biopsy revealed onion-skin type of arterial changes with necrosis, confirming the presence of scleroderma nephropathy. Electron microscopy showed diffuse fusion of foot processes. Immunohistochemical staining (IHC) revealed increased expression in glomeruli of phosphorylated mammalian target of rapamycin (p-mTOR). These findings suggest that fusion of foot processes and activation of mammalian target of rapamycin-dependent pathways in podocytes are most likely responsible for the severe proteinuria in this patient with scleroderma nephropathy.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalAnnals of Clinical and Laboratory Science
Volume38
Issue number2
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Sirolimus
Proteinuria
Fusion reactions
Kidney
Biopsy
Foot
Blood pressure
Electron microscopy
Podocytes
Creatinine
Skin
Onions
Chemical activation
Electron Microscopy
Necrosis
Staining and Labeling
Hypertension
Serum

Keywords

  • Phosphorylated mammalian target of rapamycin
  • Proteinuria
  • Scleroderma renal crisis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry

Cite this

Nepal, M., Mainali, R., Schworer, C. M., Difilippo, W., Zhang, P. L., & Schultz, M. F. (2008). Case report: Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis. Annals of Clinical and Laboratory Science, 38(2), 163-167.

Case report : Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis. / Nepal, Manish; Mainali, Roshan; Schworer, Charles M.; Difilippo, William; Zhang, Ping L.; Schultz, Michael F.

In: Annals of Clinical and Laboratory Science, Vol. 38, No. 2, 03.2008, p. 163-167.

Research output: Contribution to journalArticle

Nepal, M, Mainali, R, Schworer, CM, Difilippo, W, Zhang, PL & Schultz, MF 2008, 'Case report: Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis', Annals of Clinical and Laboratory Science, vol. 38, no. 2, pp. 163-167.
Nepal M, Mainali R, Schworer CM, Difilippo W, Zhang PL, Schultz MF. Case report: Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis. Annals of Clinical and Laboratory Science. 2008 Mar;38(2):163-167.
Nepal, Manish ; Mainali, Roshan ; Schworer, Charles M. ; Difilippo, William ; Zhang, Ping L. ; Schultz, Michael F. / Case report : Nephrotic range proteinuria: Rare manifestation of scleroderma renal crisis. In: Annals of Clinical and Laboratory Science. 2008 ; Vol. 38, No. 2. pp. 163-167.
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