Cardiovascular drug therapy in the elderly

Wilbert S. Aronow, William H. Frishman, Angela Cheng-Lai

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Pharmacokinetic considerations in the elderly include absorption, bioavailablility, drug distribution, half-life, drug metabolism, and drug excretion. There are numerous physiologic changes with aging that affect pharmacodynamics with alterations in end-organ responsiveness. This article discusses use of cardiovascular drugs in the elderly including digoxin, diuretics, β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, nitrates, calcium channel blockers, α-adrenergic blockers, antiarrhythmic drugs, lipid-lowering drugs, and anticoagulants. This article also discusses the adverse effects of cardiovascular drugs in the elderly, medications best to avoid in the elderly, and the prudent use of medications in the elderly.

Original languageEnglish (US)
Pages (from-to)195-215
Number of pages21
JournalCardiology in review
Volume15
Issue number4
DOIs
StatePublished - Jul 1 2007

Keywords

  • Cardiovascular drugs
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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