Cardiovascular drug therapy in the elderly

Wilbert S. Aronow, William H. Frishman, Angela Cheng-Lai

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pharmacokinetic considerations in the elderly include absorption, bioavailablility, drug distribution, half-life, drug metabolism, and drug excretion. There are numerous physiologic changes with aging that affect pharmacodynamics with alterations in end-organ responsiveness. This article discusses use of cardiovascular drugs in the elderly including digoxin, diuretics, β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin-II receptor blockers, nitrates, calcium channel blockers, α-adrenergic blockers, antiarrhythmic drugs, lipid-lowering drugs, and anticoagulants. This article also discusses the adverse effects of cardiovascular drugs in the elderly, medications best to avoid in the elderly, and the prudent use of medications in the elderly.

Original languageEnglish (US)
Pages (from-to)195-215
Number of pages21
JournalCardiology in Review
Volume15
Issue number4
DOIs
StatePublished - Jul 2007

Fingerprint

Cardiovascular Agents
Drug Therapy
Adrenergic Antagonists
Pharmaceutical Preparations
Angiotensin Receptor Antagonists
Anti-Arrhythmia Agents
Digoxin
Calcium Channel Blockers
Angiotensin-Converting Enzyme Inhibitors
Diuretics
Nitrates
Anticoagulants
Half-Life
Pharmacokinetics
Lipids

Keywords

  • Cardiovascular drugs
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiovascular drug therapy in the elderly. / Aronow, Wilbert S.; Frishman, William H.; Cheng-Lai, Angela.

In: Cardiology in Review, Vol. 15, No. 4, 07.2007, p. 195-215.

Research output: Contribution to journalArticle

Aronow, Wilbert S. ; Frishman, William H. ; Cheng-Lai, Angela. / Cardiovascular drug therapy in the elderly. In: Cardiology in Review. 2007 ; Vol. 15, No. 4. pp. 195-215.
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