Cardioprotective effects of autophagy: Eat your heart out, heart failure!

Gaetano Santulli

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Activation of autophagy improves post-infarction myocardial function in mice. Autophagy is an evolutionarily conserved intracellular process that mediates organelle turnover, protein degradation, and recycling of super¢uous, aging, or damaged cytoplasmic components in response to diverse stimuli, including cellular stress, ischemic injury, proteotoxicity, infection, and nutrient starvation. The functional role of autophagy in the pathophysiology of cardiovascular disorders has not been fully established, and its beneicial or detrimental effects remain quite controversial.

Original languageEnglish (US)
Article numbereaau0462
JournalScience translational medicine
Volume10
Issue number443
DOIs
StatePublished - May 30 2018

ASJC Scopus subject areas

  • Medicine(all)

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