Cardiac manifestations of neuromuscular disorders in children

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cardiac abnormalities occur in association with many of the neuromuscular disorders that present in childhood. Genetic defects involving the cytoskeleton, nuclear membrane, and mitochondrial function have all been described in patients with skeletal myopathy and cardiac involvement. The most common classes of neuromuscular disorders with cardiac manifestations are the muscular dystrophies- Duchenne, Becker, limb-girdle and Emery Dreifuss. Friedreich Ataxia and myotonic dystrophy also have important cardiac involvement. The type and extent of cardiac manifestations are specific to the type of neuromuscular disorder. The most common cardiac findings include dilated or hypertrophic cardiomyopathy, atrioventricular conduction defects, atrial fibrillation and ventricular arrhythmias. Screening for cardiac involvement should be performed in all children with neuromuscular disorders that have the potential for cardiac involvement. This review discusses the cardiac findings associated with specific neuromuscular disorders and outlines the indications for evaluation and treatment.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalPaediatric Respiratory Reviews
Volume11
Issue number1
DOIs
StatePublished - Mar 2010

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Neuromuscular Manifestations
Friedreich Ataxia
Myotonic Dystrophy
Duchenne Muscular Dystrophy
Hypertrophic Cardiomyopathy
Nuclear Envelope
Dilated Cardiomyopathy
Muscular Diseases
Cytoskeleton
Atrial Fibrillation
Cardiac Arrhythmias
Extremities
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Cardiac manifestations of neuromuscular disorders in children. / Hsu, Daphne T.

In: Paediatric Respiratory Reviews, Vol. 11, No. 1, 03.2010, p. 35-38.

Research output: Contribution to journalArticle

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