Carbon nanotubes as vaccine scaffolds

David A. Scheinberg, Michael R. McDevitt, Tao Dao, J. Justin Mulvey, Evan Feinberg, Simone Alidori

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.

Original languageEnglish (US)
Pages (from-to)2016-2022
Number of pages7
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number15
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Adjuvants
  • Antigen presenting cells
  • Carbon nanotubes
  • Vaccines

ASJC Scopus subject areas

  • Pharmaceutical Science

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