Candida glabrata Empyema Thoracis—A Post-COVID-19 Complication

Neeraja Swaminathan, Katherine Anderson, Joshua D. Nosanchuk, Matthew J. Akiyama

Research output: Contribution to journalArticlepeer-review


The COVID-19 pandemic is associated with a significant increase in the incidence of invasive mycosis, including pulmonary aspergillosis, mucormycosis, and candidiasis. Fungal empyema thoracis (FET) is an uncommon clinical presentation of invasive fungal disease (IFD) associated with significant mortality. Here, we describe the first report of a patient with post-COVID-19 multifocal necrotizing pneumonia complicated by a polymicrobial empyema that included Candida glabrata. Candida empyemas represent another manifestation of a COVID-19-associated fungal opportunistic infection, and this infrequently encountered entity requires a high degree of clinical suspicion for timely identification and management. Therapy for empyemas and other non-bloodstream Candida infections may differ from candidemia due to several pharmacokinetic parameters impacting bioavailability of the antifungal in the affected tissue (e.g., pleural space) and is an area that needs more investigation.

Original languageEnglish (US)
Article number923
JournalJournal of Fungi
Issue number9
StatePublished - Sep 2022


  • COVID-19
  • Candida empyema
  • Candida glabrata

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)


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