Cancer incidence and mortality among workers exposed to benzidine

Shannon Cameron Brown, Risa Alberts, Mark P. Schoenberg

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: A historical cohort study was conducted among 997 individuals employed at a chemical production facility to investigate whether occupational exposures to benzidine and other arylamines were associated with the increased risk of cancer. Methods: Cancers were identified from cancer registries, death certificates, and medical records. Exposures were evaluated using a job-exposure matrix. Workers were categorized into exposure groups to calculate cancer-specific standardized incidence ratios (SIRs) and perform survival analyses. Results: SIRs for cancer of the bladder (SIR=3.5; CI 1.7, 6.4), small intestine (SIR 18.4; CI 2.2, 66.4), and soft tissue including heart (SIR=11.9; CI 1.4, 42.8) were elevated among workers with the highest exposures and risk increased with increasing exposures. SIRs for several additional cancers were also elevated. Conclusion: Our results support previous findings of increased risk of bladder cancer among individuals exposed to benzidine and other arylamines. Workers may also have been at increased risk for cancers other than cancer of the bladder.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalAmerican Journal of Industrial Medicine
Volume54
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Mortality
Incidence
Urinary Bladder Neoplasms
Neoplasms
Death Certificates
Occupational Exposure
Survival Analysis
Small Intestine
Medical Records
Registries
benzidine
Cohort Studies

Keywords

  • Arylamines
  • Benzidine
  • Bladder cancer
  • Occupational

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cancer incidence and mortality among workers exposed to benzidine. / Brown, Shannon Cameron; Alberts, Risa; Schoenberg, Mark P.

In: American Journal of Industrial Medicine, Vol. 54, No. 4, 04.2011, p. 300-306.

Research output: Contribution to journalArticle

Brown, Shannon Cameron ; Alberts, Risa ; Schoenberg, Mark P. / Cancer incidence and mortality among workers exposed to benzidine. In: American Journal of Industrial Medicine. 2011 ; Vol. 54, No. 4. pp. 300-306.
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