Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.

Y. Yiting; Iti Chaturvedi; Liew Kim Meow; Pandjassarame Kangueane; Meena Kishore Sakharkar

doi:10.2741/1451

Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.

Y. Yiting, Iti Chaturvedi, Liew Kim Meow, Pandjassarame Kangueane, Meena Kishore Sakharkar

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/

Original language	English (US)
Pages (from-to)	2964-2971
Number of pages	8
Journal	Frontiers in bioscience : a journal and virtual library
Volume	9
DOIs	https://doi.org/10.2741/1451
State	Published - 2004
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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abstract = "Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/",

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AU - Meow, Liew Kim

AU - Kangueane, Pandjassarame

AU - Sakharkar, Meena Kishore

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AB - Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/

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Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.

Abstract

ASJC Scopus subject areas

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