Abstract
Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2964-2971 |
| Number of pages | 8 |
| Journal | Frontiers in Bioscience |
| Volume | 9 |
| State | Published - 2004 |
| Externally published | Yes |
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Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin. / Yiting, Y.; Chaturvedi, Iti; Meow, Liew Kim; Kangueane, Pandjassarame; Sakharkar, Meena Kishore.
In: Frontiers in Bioscience, Vol. 9, 2004, p. 2964-2971.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Can ends justify the means? Digging deep for human fusion genes of prokaryotic origin.
AU - Yiting, Y.
AU - Chaturvedi, Iti
AU - Meow, Liew Kim
AU - Kangueane, Pandjassarame
AU - Sakharkar, Meena Kishore
PY - 2004
Y1 - 2004
N2 - Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
AB - Gene fusion has been described as an important evolutionary phenomenon. This report focuses on identifying, analyzing, and tabulating human fusion proteins of prokaryotic origin. These fusion proteins are found to mimic operons, simulate protein-protein interfaces in prokaryotes, exhibiting multiple functions and alternative splicing in humans. The accredited biological functions for each of these proteins is made available as a database at http://sege.ntu.edu.sg/wester/fusion/
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UR - http://www.scopus.com/inward/citedby.url?scp=33749105321&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 2964
EP - 2971
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
ER -