Can an increased level of circulating IL-8 be a predictor of human longevity?

Katarzyna Wieczorowska-Tobis, Zofia I. Niemir, Renata Podkówka, Katarzyna Korybalska, Małgorzata Mossakowska, Andrzej Brȩborowicz

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Interleukin-6 (IL-6) and IL-8 are considered to be potent inflammatory agents. However, IL-8 has also been reported to serve as an organ protective factor. The goal of our study was to compare the circulating levels of IL-8 and IL-6 in C-reactive protein (CRP)-negative subjects of different ages. Material/Methods: Seventy subjects living in the Wielkopolska region were enrolled into the study and divided into three groups: group 1-30 young healthy subjects 21-37 years of age; group 2-30 healthy elderly individuals, age 65-87; group 3-10 centenarians (100-105 years). In all of these subjects, serum levels of IL-6 and IL-8 were assessed with an enzyme-linked immunosorbent assay. Results: Concerning IL-6, both the serum concentration and the frequency of results above the sensitivity limit were comparable in all groups. With respect to IL-8, the frequency of results beyond the sensitivity limit in groups 1 and 2 did not differ significantly (5/30 and 8/30, respectively). By contrast, the majority of subjects from group 3 had an IL-8 level above the limit (9 out of 10; p

Original languageEnglish (US)
JournalMedical Science Monitor
Volume12
Issue number3
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Interleukin-8
Interleukin-6
Serum
C-Reactive Protein
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay

Keywords

  • Elderly
  • IL-6
  • IL-8
  • Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wieczorowska-Tobis, K., Niemir, Z. I., Podkówka, R., Korybalska, K., Mossakowska, M., & Brȩborowicz, A. (2006). Can an increased level of circulating IL-8 be a predictor of human longevity? Medical Science Monitor, 12(3).

Can an increased level of circulating IL-8 be a predictor of human longevity? / Wieczorowska-Tobis, Katarzyna; Niemir, Zofia I.; Podkówka, Renata; Korybalska, Katarzyna; Mossakowska, Małgorzata; Brȩborowicz, Andrzej.

In: Medical Science Monitor, Vol. 12, No. 3, 01.03.2006.

Research output: Contribution to journalArticle

Wieczorowska-Tobis, K, Niemir, ZI, Podkówka, R, Korybalska, K, Mossakowska, M & Brȩborowicz, A 2006, 'Can an increased level of circulating IL-8 be a predictor of human longevity?', Medical Science Monitor, vol. 12, no. 3.
Wieczorowska-Tobis K, Niemir ZI, Podkówka R, Korybalska K, Mossakowska M, Brȩborowicz A. Can an increased level of circulating IL-8 be a predictor of human longevity? Medical Science Monitor. 2006 Mar 1;12(3).
Wieczorowska-Tobis, Katarzyna ; Niemir, Zofia I. ; Podkówka, Renata ; Korybalska, Katarzyna ; Mossakowska, Małgorzata ; Brȩborowicz, Andrzej. / Can an increased level of circulating IL-8 be a predictor of human longevity?. In: Medical Science Monitor. 2006 ; Vol. 12, No. 3.
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