Calicivirus enteritis in an intestinal transplant recipient

Stuart S. Kaufman, Nando K. Chatterjee, Meghan E. Fuschino, Margret S. Magid, Ronald E. Gordon, Dale L. Morse, Betsy Herold, Neal S. LeLeiko, Allan Tschernia, Sander S. Florman, Gabriel E. Gondolesi, Thomas M. Fishbein

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Protracted diarrhea of uncertain etiology is a significant problem following intestinal transplantation. We report an infant who developed severe secretory diarrhea 178 days after intestinal transplantation that persisted for more than 120 days. Repeated allograft biopsies demonstrated only nonspecific inflammation. Enzyme immunoassay (for rotavirus), culture, and reverse transcription polymerase chain reaction [calicivirus (Norwalk-like virus)] were used to identify the allograft viral infection. A heavy density of calicivirus RNA nucleotide sequences (genogroup II, strain Miami Beach) was isolated from the jejunal and ileal allograft. Following a reduction in immunosuppressive therapy, diarrhea and enteritis remitted in association with the disappearance of all calicivirus RNA sequences. Calicivirus may cause severe allograft dysfunction in intestinal transplant recipients.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalAmerican Journal of Transplantation
Volume3
Issue number6
DOIs
StatePublished - Jun 2003
Externally publishedYes

Fingerprint

Enteritis
Allografts
Diarrhea
Transplantation
Norovirus
Rotavirus
Virus Diseases
Immunosuppressive Agents
Immunoenzyme Techniques
Reverse Transcription
Genotype
Inflammation
Biopsy
Polymerase Chain Reaction
Transplant Recipients
Therapeutics

Keywords

  • Calicivirus
  • Diarrhea
  • Immunosuppression
  • Intestine
  • Norwalk virus
  • Transplant

ASJC Scopus subject areas

  • Immunology

Cite this

Kaufman, S. S., Chatterjee, N. K., Fuschino, M. E., Magid, M. S., Gordon, R. E., Morse, D. L., ... Fishbein, T. M. (2003). Calicivirus enteritis in an intestinal transplant recipient. American Journal of Transplantation, 3(6), 764-768. https://doi.org/10.1034/j.1600-6143.2003.00112.x

Calicivirus enteritis in an intestinal transplant recipient. / Kaufman, Stuart S.; Chatterjee, Nando K.; Fuschino, Meghan E.; Magid, Margret S.; Gordon, Ronald E.; Morse, Dale L.; Herold, Betsy; LeLeiko, Neal S.; Tschernia, Allan; Florman, Sander S.; Gondolesi, Gabriel E.; Fishbein, Thomas M.

In: American Journal of Transplantation, Vol. 3, No. 6, 06.2003, p. 764-768.

Research output: Contribution to journalArticle

Kaufman, SS, Chatterjee, NK, Fuschino, ME, Magid, MS, Gordon, RE, Morse, DL, Herold, B, LeLeiko, NS, Tschernia, A, Florman, SS, Gondolesi, GE & Fishbein, TM 2003, 'Calicivirus enteritis in an intestinal transplant recipient', American Journal of Transplantation, vol. 3, no. 6, pp. 764-768. https://doi.org/10.1034/j.1600-6143.2003.00112.x
Kaufman SS, Chatterjee NK, Fuschino ME, Magid MS, Gordon RE, Morse DL et al. Calicivirus enteritis in an intestinal transplant recipient. American Journal of Transplantation. 2003 Jun;3(6):764-768. https://doi.org/10.1034/j.1600-6143.2003.00112.x
Kaufman, Stuart S. ; Chatterjee, Nando K. ; Fuschino, Meghan E. ; Magid, Margret S. ; Gordon, Ronald E. ; Morse, Dale L. ; Herold, Betsy ; LeLeiko, Neal S. ; Tschernia, Allan ; Florman, Sander S. ; Gondolesi, Gabriel E. ; Fishbein, Thomas M. / Calicivirus enteritis in an intestinal transplant recipient. In: American Journal of Transplantation. 2003 ; Vol. 3, No. 6. pp. 764-768.
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