Calicivirus enteritis in an intestinal transplant recipient

Stuart S. Kaufman, Nando K. Chatterjee, Meghan E. Fuschino, Margret S. Magid, Ronald E. Gordon, Dale L. Morse, Betsy C. Herold, Neal S. LeLeiko, Allan Tschernia, Sander S. Florman, Gabriel E. Gondolesi, Thomas M. Fishbein

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Protracted diarrhea of uncertain etiology is a significant problem following intestinal transplantation. We report an infant who developed severe secretory diarrhea 178 days after intestinal transplantation that persisted for more than 120 days. Repeated allograft biopsies demonstrated only nonspecific inflammation. Enzyme immunoassay (for rotavirus), culture, and reverse transcription polymerase chain reaction [calicivirus (Norwalk-like virus)] were used to identify the allograft viral infection. A heavy density of calicivirus RNA nucleotide sequences (genogroup II, strain Miami Beach) was isolated from the jejunal and ileal allograft. Following a reduction in immunosuppressive therapy, diarrhea and enteritis remitted in association with the disappearance of all calicivirus RNA sequences. Calicivirus may cause severe allograft dysfunction in intestinal transplant recipients.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalAmerican Journal of Transplantation
Volume3
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Calicivirus
  • Diarrhea
  • Immunosuppression
  • Intestine
  • Norwalk virus
  • Transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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  • Cite this

    Kaufman, S. S., Chatterjee, N. K., Fuschino, M. E., Magid, M. S., Gordon, R. E., Morse, D. L., Herold, B. C., LeLeiko, N. S., Tschernia, A., Florman, S. S., Gondolesi, G. E., & Fishbein, T. M. (2003). Calicivirus enteritis in an intestinal transplant recipient. American Journal of Transplantation, 3(6), 764-768. https://doi.org/10.1034/j.1600-6143.2003.00112.x