Brief report: Parental age and the sex ratio in autism

Alene Anello; Abraham Reichenberg; Xiaodong Luo; James Schmeidler; Eric Hollander; Christopher J. Smith; Connor M. Puleo; Lauren A. Kryzak; Jeremy M. Silverman

doi:10.1007/s10803-009-0755-y

Brief report: Parental age and the sex ratio in autism

Alene Anello, Abraham Reichenberg, Xiaodong Luo, James Schmeidler, Eric Hollander, Christopher J. Smith, Connor M. Puleo, Lauren A. Kryzak, Jeremy M. Silverman

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

Original language	English (US)
Pages (from-to)	1487-1492
Number of pages	6
Journal	Journal of Autism and Developmental Disorders
Volume	39
Issue number	10
DOIs	https://doi.org/10.1007/s10803-009-0755-y
State	Published - 2009
Externally published	Yes

Keywords

Copy number variants
Genetics
Genomic anomalies
Maternal age
Paternal age
Sex ratio

ASJC Scopus subject areas

Developmental and Educational Psychology

Access to Document

10.1007/s10803-009-0755-y

Fingerprint Dive into the research topics of 'Brief report: Parental age and the sex ratio in autism'. Together they form a unique fingerprint.

Cite this

Brief report : Parental age and the sex ratio in autism. / Anello, Alene; Reichenberg, Abraham; Luo, Xiaodong; Schmeidler, James; Hollander, Eric; Smith, Christopher J.; Puleo, Connor M.; Kryzak, Lauren A.; Silverman, Jeremy M.

In: Journal of Autism and Developmental Disorders, Vol. 39, No. 10, 2009, p. 1487-1492.

Research output: Contribution to journal › Article › peer-review

@article{632887233e2a45b0a01289ee19499da1,

title = "Brief report: Parental age and the sex ratio in autism",

abstract = "The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.",

keywords = "Copy number variants, Genetics, Genomic anomalies, Maternal age, Paternal age, Sex ratio",

author = "Alene Anello and Abraham Reichenberg and Xiaodong Luo and James Schmeidler and Eric Hollander and Smith, {Christopher J.} and Puleo, {Connor M.} and Kryzak, {Lauren A.} and Silverman, {Jeremy M.}",

year = "2009",

doi = "10.1007/s10803-009-0755-y",

language = "English (US)",

volume = "39",

pages = "1487--1492",

journal = "Journal of Autism and Developmental Disorders",

issn = "0162-3257",

publisher = "Springer New York",

number = "10",

}

TY - JOUR

T1 - Brief report

T2 - Parental age and the sex ratio in autism

AU - Anello, Alene

AU - Reichenberg, Abraham

AU - Luo, Xiaodong

AU - Schmeidler, James

AU - Hollander, Eric

AU - Smith, Christopher J.

AU - Puleo, Connor M.

AU - Kryzak, Lauren A.

AU - Silverman, Jeremy M.

PY - 2009

Y1 - 2009

N2 - The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

AB - The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

KW - Copy number variants

KW - Genetics

KW - Genomic anomalies

KW - Maternal age

KW - Paternal age

KW - Sex ratio

UR - http://www.scopus.com/inward/record.url?scp=70349601666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349601666&partnerID=8YFLogxK

U2 - 10.1007/s10803-009-0755-y

DO - 10.1007/s10803-009-0755-y

M3 - Article

C2 - 19452267

AN - SCOPUS:70349601666

VL - 39

SP - 1487

EP - 1492

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 10

ER -