Brief report: Parental age and the sex ratio in autism

Alene Anello; Abraham Reichenberg; Xiaodong Luo; James Schmeidler; Eric Hollander; Christopher J. Smith; Connor M. Puleo; Lauren A. Kryzak; Jeremy M. Silverman

doi:10.1007/s10803-009-0755-y

Brief report: Parental age and the sex ratio in autism

Alene Anello, Abraham Reichenberg, Xiaodong Luo, James Schmeidler, Eric Hollander, Christopher J. Smith, Connor M. Puleo, Lauren A. Kryzak, Jeremy M. Silverman

Research output: Contribution to journal › Article

28 Scopus citations

Abstract

The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.

Original language	English (US)
Pages (from-to)	1487-1492
Number of pages	6
Journal	Journal of Autism and Developmental Disorders
Volume	39
Issue number	10
DOIs	https://doi.org/10.1007/s10803-009-0755-y
State	Published - 2009
Externally published	Yes

Keywords

Copy number variants
Genetics
Genomic anomalies
Maternal age
Paternal age
Sex ratio

ASJC Scopus subject areas

Developmental and Educational Psychology

Access to Document

10.1007/s10803-009-0755-y

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Cite this

Anello, A., Reichenberg, A., Luo, X., Schmeidler, J., Hollander, E., Smith, C. J., Puleo, C. M., Kryzak, L. A., & Silverman, J. M. (2009). Brief report: Parental age and the sex ratio in autism. Journal of Autism and Developmental Disorders, 39(10), 1487-1492. https://doi.org/10.1007/s10803-009-0755-y

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abstract = "The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.",

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AU - Smith, Christopher J.

AU - Puleo, Connor M.

AU - Kryzak, Lauren A.

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