Abstract
The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1487-1492 |
| Number of pages | 6 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 39 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Copy number variants
- Genetics
- Genomic anomalies
- Maternal age
- Paternal age
- Sex ratio
ASJC Scopus subject areas
- Developmental and Educational Psychology
Cite this
Brief report : Parental age and the sex ratio in autism. / Anello, Alene; Reichenberg, Abraham; Luo, Xiaodong; Schmeidler, James; Hollander, Eric; Smith, Christopher J.; Puleo, Connor M.; Kryzak, Lauren A.; Silverman, Jeremy M.
In: Journal of Autism and Developmental Disorders, Vol. 39, No. 10, 2009, p. 1487-1492.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brief report
T2 - Parental age and the sex ratio in autism
AU - Anello, Alene
AU - Reichenberg, Abraham
AU - Luo, Xiaodong
AU - Schmeidler, James
AU - Hollander, Eric
AU - Smith, Christopher J.
AU - Puleo, Connor M.
AU - Kryzak, Lauren A.
AU - Silverman, Jeremy M.
PY - 2009
Y1 - 2009
N2 - The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.
AB - The male-to-female (M:F) ratio for autism spectrum disorders (ASD), typically about 4:1, appears to decrease with increasing paternal age, but this relationship has not been systematically tested. With 393 ASD cases from families with two or more ASD cases, we categorized paternal age into five age groups (<30, 30-34, 35-39, 40-44, 45+) and found that the M:F ratio was significantly decreased with increasing paternal age groups and remained so after also adjusting for maternal age. No significant relationship between maternal age group and the M:F ratio was observed. This study suggests that the M:F ratio is reduced with increasing paternal age consistent with de novo genetic or genomic anomalies arising more frequently as men age and then conceive children.
KW - Copy number variants
KW - Genetics
KW - Genomic anomalies
KW - Maternal age
KW - Paternal age
KW - Sex ratio
UR - http://www.scopus.com/inward/record.url?scp=70349601666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349601666&partnerID=8YFLogxK
U2 - 10.1007/s10803-009-0755-y
DO - 10.1007/s10803-009-0755-y
M3 - Article
C2 - 19452267
AN - SCOPUS:70349601666
VL - 39
SP - 1487
EP - 1492
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 10
ER -