Brentuximab Vedotin (Adcetris®) for the Treatment of CD30-Positive Hematologic Malignancies

Niels W.C.J. Van De Donk, Eugen Dhimolea

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Brentuximab vedotin (SGN-35; Adcetris®) is an anti-CD30 antibody conjugated via a protease-cleavable linker to the potent anti-microtubule agent monomethyl auristatin E (MMAE). Following binding to CD30, brentuximab vedotin is rapidly internalized and transported to lysosomes where MMAE is released and binds to tubulin, leading to cell cycle arrest and apoptosis. Several trials have shown durable antitumor activity with a manageable safety profile in patients with relapsed/refractory systemic anaplastic large cell lymphoma, Hodgkin lymphoma, or primary cutaneous CD30-positive lymphoproliferative disorders. Peripheral sensory neuropathy is a significant adverse event associated with brentuximab vedotin administration. Neuropathy symptoms are cumulative and dose-related. Multiple ongoing trials are currently evaluating brentuximab vedotin alone or in combination with other agents in relapsed/refractory patients, as well as in patients with newly diagnosed disease.

Original languageEnglish (US)
Title of host publicationApproved Therapeutic Antibodies
PublisherWiley-Blackwell
Pages1417-1444
Number of pages28
Volume3-4
ISBN (Electronic)9783527682423
ISBN (Print)9783527329373
DOIs
StatePublished - Dec 3 2014
Externally publishedYes

Keywords

  • Anaplastic large cell lymphoma
  • Brentuximab vedotin
  • CD30
  • Hodgkin lymphoma
  • Immunotherapy
  • Monoclonal antibody

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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