Brain structure covariance associated with gait control in aging

Gilles Allali, Maxime Montembeault, Simona M. Brambati, Louis Bherer, Helena M. Blumen, Cyrille P. Launay, Teresa Liu-Ambrose, Jorunn L. Helbostad, Joe Verghese, Olivier Beauchet

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Structural and functional brain imaging methods have identified age-related changes in brain structures involved in gait control. This cross-sectional study aims to investigate gray matter networks associated with gait control in aging using structural covariance analysis. Methods: Walking speed were measured in 326 nondemented older community-dwellers (age 71.3 ± 4.5; 41.7% female) under three different walking conditions: normal walking and two challenging tasks: motor (ie, fast speed) and an attention-demanding dual task (ie, backward counting). Results: Three main individual gray matter regions were positively correlated with walking speed (ie, slower walking speed was associated with lower brain volumes): right thalamus, right caudate nucleus, and left middle frontal gyrus for normal walking, rapid walking, and dual-task walking condition, respectively. The structural covariance analysis revealed that prefrontal regions were part of the networks associated with every walking condition; the right caudate was associated specifically with the hippocampus, amygdala and insula for the rapid walking condition, and the left middle frontal gyrus with a network involving the cuneus for the dual-task condition. Conclusion: Our results suggest that brain networks associated with gait control vary according to walking speed and depend on each walking condition. Gait control in aging involved a distributed network including regions for emotional control that are recruited in challenging walking conditions.

Original languageEnglish (US)
Pages (from-to)705-713
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume74
Issue number5
DOIs
StatePublished - May 1 2019

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Gait
Walking
Brain
Occipital Lobe
Functional Neuroimaging
Caudate Nucleus
Amygdala
Thalamus
Hippocampus
Cross-Sectional Studies
Walking Speed

Keywords

  • Aging
  • Anatomical structural covariance
  • Gait
  • Motor control
  • Neuroimaging

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Brain structure covariance associated with gait control in aging. / Allali, Gilles; Montembeault, Maxime; Brambati, Simona M.; Bherer, Louis; Blumen, Helena M.; Launay, Cyrille P.; Liu-Ambrose, Teresa; Helbostad, Jorunn L.; Verghese, Joe; Beauchet, Olivier.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 74, No. 5, 01.05.2019, p. 705-713.

Research output: Contribution to journalArticle

Allali, G, Montembeault, M, Brambati, SM, Bherer, L, Blumen, HM, Launay, CP, Liu-Ambrose, T, Helbostad, JL, Verghese, J & Beauchet, O 2019, 'Brain structure covariance associated with gait control in aging', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 74, no. 5, pp. 705-713. https://doi.org/10.1093/gerona/gly123
Allali, Gilles ; Montembeault, Maxime ; Brambati, Simona M. ; Bherer, Louis ; Blumen, Helena M. ; Launay, Cyrille P. ; Liu-Ambrose, Teresa ; Helbostad, Jorunn L. ; Verghese, Joe ; Beauchet, Olivier. / Brain structure covariance associated with gait control in aging. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2019 ; Vol. 74, No. 5. pp. 705-713.
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