Brain imaging of locomotion in neurological conditions

Gilles Allali, Helena M. Blumen, Hervé Devanne, Elvira Pirondini, Arnaud Delval, Dimitri Van De Ville

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i.e., MRI) or functional (i.e., functional MRI or functional near infra-red spectroscopy) brain imaging, electrophysiology (i.e., EEG), non-invasive brain stimulation (i.e., transcranial magnetic stimulation, or transcranial direct current stimulation) or molecular imaging methods (i.e., PET, or SPECT) reveal extended brain networks involving both grey and white matters in key cortical (i.e., prefrontal cortex) and subcortical (basal ganglia and cerebellum) regions associated with locomotion. However, the specific roles of the various pathophysiological mechanisms encountered in each neurological condition on the phenotype of gait disorders still remains unclear. After reviewing the results of individual brain imaging techniques across the common neurological conditions, such as Parkinson's disease, dementia, stroke, or multiple sclerosis, we will discuss how the development of new imaging techniques and computational analyses that integrate multivariate correlations in “large enough datasets” might help to understand how individual pathophysiological mechanisms express clinically as an abnormal gait. Finally, we will explore how these new analytic methods could drive our rehabilitative strategies.

Original languageEnglish (US)
Pages (from-to)337-359
Number of pages23
JournalNeurophysiologie Clinique
Volume48
Issue number6
DOIs
StatePublished - Dec 2018

Keywords

  • Dementia
  • Gait disorders
  • Methods
  • Multiple Sclerosis.
  • Neuroimaging
  • Neurological conditions
  • Parkinson's disease
  • Review
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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  • Cite this

    Allali, G., Blumen, H. M., Devanne, H., Pirondini, E., Delval, A., & Van De Ville, D. (2018). Brain imaging of locomotion in neurological conditions. Neurophysiologie Clinique, 48(6), 337-359. https://doi.org/10.1016/j.neucli.2018.10.004