Brain imaging of locomotion in neurological conditions

Gilles Allali, Helena M. Blumen, Hervé Devanne, Elvira Pirondini, Arnaud Delval, Dimitri Van De Ville

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i.e., MRI) or functional (i.e., functional MRI or functional near infra-red spectroscopy) brain imaging, electrophysiology (i.e., EEG), non-invasive brain stimulation (i.e., transcranial magnetic stimulation, or transcranial direct current stimulation) or molecular imaging methods (i.e., PET, or SPECT) reveal extended brain networks involving both grey and white matters in key cortical (i.e., prefrontal cortex) and subcortical (basal ganglia and cerebellum) regions associated with locomotion. However, the specific roles of the various pathophysiological mechanisms encountered in each neurological condition on the phenotype of gait disorders still remains unclear. After reviewing the results of individual brain imaging techniques across the common neurological conditions, such as Parkinson's disease, dementia, stroke, or multiple sclerosis, we will discuss how the development of new imaging techniques and computational analyses that integrate multivariate correlations in “large enough datasets” might help to understand how individual pathophysiological mechanisms express clinically as an abnormal gait. Finally, we will explore how these new analytic methods could drive our rehabilitative strategies.

Original languageEnglish (US)
JournalNeurophysiologie Clinique
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Locomotion
Neuroimaging
Gait
Brain
Parkinson Disease
Magnetic Resonance Imaging
Molecular Imaging
Transcranial Magnetic Stimulation
Electrophysiology
Imagery (Psychotherapy)
Basal Ganglia
Prefrontal Cortex
Single-Photon Emission-Computed Tomography
Cerebellum
Multiple Sclerosis
Walking
Dementia
Electroencephalography
Spectrum Analysis
Multivariate Analysis

Keywords

  • Dementia
  • Gait disorders
  • Methods
  • Multiple Sclerosis.
  • Neuroimaging
  • Neurological conditions
  • Parkinson's disease
  • Review
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Allali, G., Blumen, H. M., Devanne, H., Pirondini, E., Delval, A., & Van De Ville, D. (Accepted/In press). Brain imaging of locomotion in neurological conditions. Neurophysiologie Clinique. https://doi.org/10.1016/j.neucli.2018.10.004

Brain imaging of locomotion in neurological conditions. / Allali, Gilles; Blumen, Helena M.; Devanne, Hervé; Pirondini, Elvira; Delval, Arnaud; Van De Ville, Dimitri.

In: Neurophysiologie Clinique, 01.01.2018.

Research output: Contribution to journalArticle

Allali, Gilles ; Blumen, Helena M. ; Devanne, Hervé ; Pirondini, Elvira ; Delval, Arnaud ; Van De Ville, Dimitri. / Brain imaging of locomotion in neurological conditions. In: Neurophysiologie Clinique. 2018.
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