Brachiola vesicularum, n. g., n. sp., a new microsporidium associated with AIDS and myositis

Ann Cali, Peter M. Takvorian, Sharon Lewin, Michael Rendel, Corazon S. Sian, Murray Wittner, Herbert B. Tanowitz, Elaine Keohane, Louis M. Weiss

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Brachiola vesicularum, n. g., n. sp., is a new microsporidium associated with AIDS and myositis. Biopsied muscle tissue, examined by light and electron microscopy, revealed the presence of organisms developing in direct contact with muscle cell cytoplasm and fibers. No other tissue types were infected. All parasite stages contain diplokaryotic nuclei and all cell division is by binary fission. Sporogony is disporoblastic, producing 2.9 x 2 μm diplokaryotic spores containing 8-10 coils of the polar filament arranged in one to three rows, usually two. Additionally, this microsporidium produces electron-dense extracellular secretions and vesiculotubular appendages similar to Nosema algerae. However, the production of protoplasmic extensions which may branch and terminate in extensive vesiculotubular structures is unique to this parasite. Additionally, unlike Nosema algerae, its development occurred at warm blooded host temperature (37-38°C) and unlike Nosema connori, which disseminates to all tissue types, B. vesicularum infected only muscle cells. Thus, a new genus and species is proposed. Because of the similarities with the genus Nosema, this new genus is placed in the family Nosematidae. Successful clearing of this infection (both clinically and histologically) resulted from treatment with albendazole and itraconozole.

Original languageEnglish (US)
Pages (from-to)240-251
Number of pages12
JournalJournal of Eukaryotic Microbiology
Volume45
Issue number3
StatePublished - May 1 1998

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Keywords

  • Appendages
  • Microspora
  • Microsporidiosis
  • Morphogenesis
  • Muscle tissue
  • Nosematidae
  • Protoplasmic extensions
  • Taxonomy
  • Tubules
  • Vesiculotubular structures

ASJC Scopus subject areas

  • Microbiology

Cite this

Cali, A., Takvorian, P. M., Lewin, S., Rendel, M., Sian, C. S., Wittner, M., Tanowitz, H. B., Keohane, E., & Weiss, L. M. (1998). Brachiola vesicularum, n. g., n. sp., a new microsporidium associated with AIDS and myositis. Journal of Eukaryotic Microbiology, 45(3), 240-251.