Blastomyces dermatitidis produces melanin in vitro and during infection

Joshua D. Nosanchuk, David Van Duin, Piyali Mandal, Philip Aisen, Alfred M. Legendre, Arturo Casadevall

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Melanin is made by several important pathogenic fungi and is implicated in the pathogenesis of a number of mycoses. This study investigates whether the thermally dimorphic fungal pathogen Blastomyces dermatitidis produces melanin. Using techniques developed to study melanization in other fungi, we demonstrate that B. dermatitidis conidia and yeast produce melanin in vitro and that yeast cells synthesize melanin or melanin-like pigment in vivo. Melanization reduced susceptibility to amphotericin B, but not to itraconazole or voriconazole. Since melanin is an important virulence factor in other pathogenic fungi, this pigment may affect the pathogenesis of blastomycosis.

Original languageEnglish (US)
Pages (from-to)187-193
Number of pages7
JournalFEMS Microbiology Letters
Volume239
Issue number1
DOIs
StatePublished - Oct 1 2004

Keywords

  • Blastomyces dermatitidis
  • Fungi
  • Melanin
  • Virulence factor

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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